The panel of assays in the TaqMan® Mouse Alzheimer 's Array is based on the ‘amyloid hypothesis’. The 92 genes are involved in APP processes that generate beta-amyloid and included genes implicated in multiple secondary steps of beta-amyloid aggregation, tau hyperphosphorylation, excitotoxicity, inflammation, oxidation and microglial activation. We also include assays for genes involved in cholesterol biosynthesis due to the correlation between high cholesterol and increased ...
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Abca1, Ache, Adam10, Adam17, Adam9, Ager, Apba1, Apba2, Apba3, Apbb1, Apbb2, Apbb3, Apcs, Aph1a, Aph1b, Aplp1, Aplp2, Apoe, App, Appbp1, Bace1, Bace2, Bche, Capn1, Capns1, Casp3, Casp6, Cdc2a, Cdk5, Cdk5r1, Chat, Chrm1, Chrm3, Chrna4, Chrna7, Csnk1a1, Csnk1d, Ctsb, Ctsc, Ctsd, Ctsg, Cyp46a1, Falz, Gal, Gap43, Gapdh, Gj...
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18S
Alzheimer’s disease is a progressive and fatal neurodegenerative disorder. The disease has a characteristic neuropathology—cerebral plaques containing beta-amyloid deposits and neurofibrillary tangles composed of the microtubule-associated protein tau. Th ...
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