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Invitrogen
Caveolin 1 Monoclonal Antibody (Z034)
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FIGURE: 1 / 8
Caveolin 1 Antibody (03-6000) in WB
Knockout of Caveolin 1 was achieved by CRISPR-Cas9 genome editing using LentiArray™ Lentiviral sgRNA (Product # A32042, Assay ID CRISPR639775_LV) and LentiArray Cas9 Lentivirus (Product # A32064). Western blot analysis of Caveolin 1 was performed by loading 30 µg of HeLa Cas9 (Lane 1), HeLa Cas9 treated with 25 nm Paclitaxel for 24 hrs (Lane 2), HeLa Caveolin 1 KO (Lane 3) and HeLa Caveolin 1 KO treated with 25 nm Paclitaxel for 24 hrs (Lane 4) whole cell extracts. The samples were electrophoresed using NuPAGE™ Novex™ 4-12% Bis-Tris Prote... View More
Product Details
03-6000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Hamster,
Human,
Mouse,
Non-human primate,
Protozoa,
Rabbit
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
Z034
Immunogen
Tyrosine-phosphorylated proteins from RSV-transformed chick embryo fibroblasts
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; Caveolin-1; cell growth-inhibiting protein 32; GIG32; HGNC:1527; OTTHUMP00000196475; unnamed protein product
Gene Aliases: BSCL3; CAV; CAV1; CGL3; LCCNS; MSTP085; PPH3; VIP21
UniProt ID: (Human) Q03135
Entrez Gene ID: (Human) 857
receptor binding
patched binding
protein binding
oxysterol binding
cholesterol binding
peptidase activator activity
enzyme binding
protein kinase binding
protein tyrosine kinase inhibitor activity
protein binding, bridging
small GTPase binding
nitric-oxide synthase inhibitor activity
identical protein binding
ion channel binding
macromolecular complex binding
protein heterodimerization activity
nitric-oxide synthase binding
ATPase binding
binding, bridging
inward rectifier potassium channel inhibitor activity
protein sequestering activity
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
angiogenesis
vasculogenesis
response to hypoxia
endothelial cell proliferation
negative regulation of endothelial cell proliferation
negative regulation of cytokine-mediated signaling pathway
regulation of the force of heart contraction
glandular epithelial cell differentiation
response to ischemia
regulation of the force of heart contraction by chemical signal
triglyceride metabolic process
nitric oxide biosynthetic process
calcium ion transport
cellular calcium ion homeostasis
regulation of smooth muscle contraction
skeletal muscle tissue development
lactation
protein localization
cell proliferation
negative regulation of cell proliferation
cellular response to starvation
response to bacterium
negative regulation of signal transduction
positive regulation of calcium ion transport into cytosol
posttranscriptional regulation of gene expression
positive regulation of gene expression
positive regulation of cholesterol efflux
protein transport
vesicle organization
receptor-mediated endocytosis of virus by host cell
regulation of fatty acid metabolic process
cytokine-mediated signaling pathway
lipid storage
cell differentiation
regulation of blood coagulation
cholesterol transport
positive regulation of cell migration
negative regulation of BMP signaling pathway
negative regulation of epithelial cell differentiation
mammary gland development
T cell costimulation
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
receptor internalization
maintenance of protein location in cell
response to progesterone
nitric oxide homeostasis
toll-like receptor 4 signaling pathway
regulation of toll-like receptor 4 signaling pathway
insulin receptor internalization
angiotensin-activated signaling pathway
vasoconstriction
cholesterol homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAPK cascade
response to estrogen
protein localization to plasma membrane raft
negative regulation of nitric oxide biosynthetic process
positive regulation of vasoconstriction
nitric oxide metabolic process
negative regulation of JAK-STAT cascade
muscle cell cellular homeostasis
fibroblast proliferation
negative regulation of fibroblast proliferation
negative regulation of pinocytosis
regulation of cytosolic calcium ion concentration
response to calcium ion
establishment of localization in cell
membrane depolarization
calcium ion homeostasis
mammary gland involution
canonical Wnt signaling pathway
negative regulation of necroptotic process
caveola assembly
cellular response to misfolded protein
cellular response to peptide hormone stimulus
cellular response to hyperoxia
cellular response to transforming growth factor beta stimulus
basement membrane organization
caveolin-mediated endocytosis
regulation of heart rate by cardiac conduction
negative regulation of canonical Wnt signaling pathway
apoptotic signaling pathway
regulation of membrane repolarization during action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of ventricular cardiac muscle cell action potential
positive regulation of cold-induced thermogenesis
regulation of ruffle assembly
negative regulation of potassium ion transmembrane transport
regulation of cell communication by electrical coupling involved in cardiac conduction
protein localization to basolateral plasma membrane
positive regulation of gap junction assembly
positive regulation of ERAD pathway
regulation of entry of bacterium into host cell
negative regulation of anoikis
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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