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Proteintech
TFII I Polyclonal Antibody
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Product Details
10499-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TFII I Fusion Protein Ag0773 (1-274 aa encoded by BC004472)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Amount
36 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAQVAMSTL PVEDEESSES RMVVTFLMSA LESMCKELAK SKAEVACIAV YETDVFVVGT ERGRAFVNTR KDFQKDFVKY CVEEEEKAAE MHKMKSTTQA NRMSVDAVEI ETLRKTVEDY FCFCYGKALG KSTVVPVPYE KMLRDQSAVV VQGLPEGVAF KHPENYDLAT LKWILENKAG ISFIIKRPFL EPKKHVGGRV MVTDADRSIL SPGGSCGPIK VKTEPTEDSG ISLEMAAVTV KEESEDPDYY QYNIQGSHHS SEGNEGTEME VPAEG (1-274 aa encoded by BC004472)
Target Information
This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11. 23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BAP-135; Bruton tyrosine kinase-associated protein 135; BTK-associated protein 135; BTK-associated protein, 135kD; General transcription factor II-I; GTFII-I; Mutations: 192:OK; OTTHUMP00000209509; protein kinase substrate; SPIN; SRF-Phox1-interacting protein; TFII-I; tfiii; unnamed protein product; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
Gene Aliases: 6030441I21Rik; BAP-135; BAP135; BTKAP1; DIWS; Diws1t; GTF2I; Gtf2ird1; GTFII-I; IB291; SPIN; TFII-I; WBS; WBSCR6
UniProt ID: (Human) P78347, (Rat) Q5U2Y1, (Mouse) Q9ESZ8
Entrez Gene ID: (Human) 2969, (Rat) 353256, (Mouse) 14886
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
molecular_function
mitogen-activated protein kinase binding
general transcription factor
transcription from RNA polymerase II promoter
negative regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transition between slow and fast fiber
negative regulation of cytosolic calcium ion concentration
embryo development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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