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Proteintech
DDR1 Polyclonal Antibody
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Product Details
10536-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DDR1 Fusion Protein Ag0794 (4-403 aa encoded by BC008716)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EALSSLLLL LLVASGDADM KGHFDPAKCR YALGMQDRTI PDSDISASSS WSDSTAARHS RLESSDGDGA WCPAGSVFPK EEEYLQVDLQ RLHLVALVGT QGRHAGGLGK EFSRSYRLRY SRDGRRWMGW KDRWGQEVIS GNEDPEGVVL KDLGPPMVAR LVRFYPRADR VMSVCLRVEL YGCLWRDGLL SYTAPVGQTM YLSEAVYLND STYDGHTVGG LQYGGLGQLA DGVVGLDDFR KSQELRVWPG YDYVGWSNHS FSSGYVEMEF EFDRLRAFQA MQVHCNNMHT LGARLPGGVE CRFRRGPAMA WEGEPMRHNL GGNLGDPRAR AVSVPLGGRV ARFLQCRFLF AGPWLLFSEI SFISDVVNNS SPALGGTFPP APWWPPGPPP TNFSSLELEP R (4-403 aa encoded by BC008716)
Target Information
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DAAP-278B20.1; DDR1d; Discoidin receptor tyrosine kinase; Epithelial discoidin domain receptor 1; Epithelial discoidin domain-containing receptor 1; HGK2; juxtamembrane region; Mammary carcinoma kinase 10; MCK-10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; PTK3A protein tyrosine kinase 3A; TRK E; Tyrosine kinase DDR; Tyrosine-protein kinase CAK; unnamed protein product
Gene Aliases: CAK; CD167; DDR; DDR1; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
UniProt ID: (Human) Q08345
Entrez Gene ID: (Human) 780
regulation of cell growth
regulation of cell-matrix adhesion
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
female pregnancy
embryo implantation
lactation
cell proliferation
negative regulation of cell proliferation
regulation of extracellular matrix disassembly
positive regulation of neuron projection development
smooth muscle cell migration
collagen-activated tyrosine kinase receptor signaling pathway
peptidyl-tyrosine autophosphorylation
ear development
wound healing, spreading of cells
protein autophosphorylation
positive regulation of protein kinase B signaling
branching involved in mammary gland duct morphogenesis
mammary gland alveolus development
smooth muscle cell-matrix adhesion
axon development
neuron projection extension
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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