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NeoBiotechnologies
CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Rabbit Monoclonal Antibody (CFTR, 1775R)
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FIGURE: 1 / 2
CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody (1080-RBM5-P1) in IHC (P)
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human pancreas using CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Monoclonal Antibody (Product # 1080-RBM5-P1).
Product Details
1080-RBM5-P1
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
CFTR, 1775R
Immunogen
Recombinant fragment (around aa 258-385) of human CFTR protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP Binding Cassette Superfamily C Member 7 (ABCC7); ATP-binding cassette sub-family C member 7; cAMP-dependent chloride channel; CFTR; Channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulating; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator isoform; tcag7.78; TNR CFTR
Gene Aliases: ABC35; ABCC7; CF; CFTR; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR
UniProt ID: (Human) P13569
Entrez Gene ID: (Human) 1080
nucleotide binding
chloride channel activity
channel-conductance-controlling ATPase activity
protein binding
ATP binding
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
isomerase activity
ATPase activity
chloride channel regulator activity
chloride channel inhibitor activity
enzyme binding
PDZ domain binding
anion transmembrane-transporting ATPase activity
chaperone binding
14-3-3 protein binding
Sec61 translocon complex binding
ABC-type transporter activity
cholesterol biosynthetic process
ion transport
chloride transport
water transport
vesicle docking involved in exocytosis
bicarbonate transport
cholesterol transport
ion transmembrane transport
response to endoplasmic reticulum stress
transepithelial water transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of exocytosis
sperm capacitation
multicellular organismal water homeostasis
intracellular pH elevation
establishment of localization in cell
transmembrane transport
membrane hyperpolarization
regulation of biological quality
positive regulation of enamel mineralization
cellular response to cAMP
amelogenesis
inorganic ion transmembrane transport
chloride transmembrane transport
positive regulation of voltage-gated chloride channel activity
cellular response to forskolin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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