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Proteintech
IRSp53 Polyclonal Antibody
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Product Details
11087-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IRSp53 Fusion Protein Ag1552 (1-300 aa encoded by BC014020)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSLSRSEEM HRLTENVYKT IMEQFNPSLR NFIAMGKNYE KALAGVTYAA KGYFDALVKM GELASESQGS KELGDVLFQM AEVHRQIQNQ LEEMLKSFHN ELLTQLEQKV ELDSRYLSAA LKKYQTEQRS KGDALDKCQA ELKKLRKKSQ GSKNPQKYSD KELQYIDAIS NKQGELENYV SDGYKTALTE ERRRFCFLVE KQCAVAKNSA AYHSKGKELL AQKLPLWQQA CADPSKIPER AVQLMQQVAS NGATLPSALS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQESTPIM N (1-300 aa encoded by BC014020)
Target Information
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BAI-associated protein 2; BAI1 associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; FLAF3; insulin receptor substrate 53; insulin receptor substrate of 53 kDa; insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; Insulin receptor tyrosine kinase 53 kDa substrate; Insulin receptor tyrosine kinase substrate protein p53; IRS-58; IRSp53; IRSp53/58; unnamed protein product; WASP and MIM like
Gene Aliases: BAIAP2; BAP2; FLAF3; IRSP53; R75030; WAML
UniProt ID: (Human) Q9UQB8, (Mouse) Q8BKX1, (Rat) Q6GMN2
Entrez Gene ID: (Human) 10458, (Mouse) 108100, (Rat) 117542
plasma membrane organization
axonogenesis
insulin receptor signaling pathway
regulation of cell shape
positive regulation of neuron projection development
dendrite development
neuron differentiation
positive regulation of actin filament polymerization
regulation of actin cytoskeleton organization
protein localization to synapse
regulation of synaptic plasticity
modulation of synaptic transmission
actin filament bundle assembly
actin crosslink formation
positive regulation of dendritic spine morphogenesis
cellular response to epidermal growth factor stimulus
cell-cell adhesion
regulation of postsynapse organization
cellular response to L-glutamate
regulation of modification of postsynaptic actin cytoskeleton
positive regulation of excitatory postsynaptic potential
Rho protein signal transduction
response to bacterium
positive regulation of actin cytoskeleton reorganization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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