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Proteintech
HNRNPA1 Polyclonal Antibody
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Product Details
11176-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Published species
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HNRNPA1 Fusion Protein Ag1656 (1-320 aa encoded by BC009600)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSKSESPKE PEQLRKLFIG GLSFETTDES LRSHFEQWGT LTDCVVMRDP NTKRSRGFGF VTYATVEEVD AAMNARPHKV DGRVVEPKRA VSREDSQRPG AHLTVKKIFV GGIKEDTEEH HLRDYFEQYG KIEVIEIMTD RGSGKKRGFA FVTFDDHDSV DKIVIQKYHT VNGHNCEVRK ALSKQEMASA SSSQRGRSGS GNFGGGRGGG FGGNDNFGRG GNFSGRGGFG GSRGGGGYGG SGDGYNGFGN DGSNFGGGGS YNDFGNYNNQ SSNFGPMKGG NFGGRSSGPY GGGGQYFAKP RNQGGYGGSS SSSSYGSGRR F (1-320 aa encoded by BC009600)
Target Information
HnRNP A1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re imported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; HDP-1; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP A1-like 3; hnRNP core protein A1; hnRNP core protein A1-like 3; hnRNP I; HNRNP-I; HNRNPI; HNRPA1MGC102835; HNRPI; MGC102835; nuclear ribonucleoprotein particle A1 protein; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; putative heterogeneous nuclear ribonucleoprotein A1-like 3; RP11-78J21.1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein; Single-strand-binding protein; Topoisomerase-inhibitor suppressed; unnamed protein product
Gene Aliases: ALS19; ALS20; Fli-2; Hdp; HDP-1; hnRNP A1; hnRNP-A1; HNRNPA1; HNRPA1; HNRPA1L3; IBMPFD3; MPD3; ROA1; Tis; UP 1
UniProt ID: (Human) P09651, (Mouse) P49312
Entrez Gene ID: (Pig) 768103, (Human) 3178, (Mouse) 15382
nucleic acid binding
DNA binding
single-stranded DNA binding
RNA binding
single-stranded RNA binding
mRNA 3'-UTR binding
protein binding
protein domain specific binding
miRNA binding
pre-mRNA binding
identical protein binding
telomeric repeat-containing RNA binding
G-rich strand telomeric DNA binding
nucleotide binding
alternative mRNA splicing, via spliceosome
mRNA processing
transport
RNA splicing
mRNA transport
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
RNA export from nucleus
negative regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomerase
cellular response to glucose starvation
regulation of RNA splicing
nuclear export
nuclear import
cellular response to sodium arsenite
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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