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Proteintech
alpha Actinin Polyclonal Antibody
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Product Details
11313-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
alpha Actinin Fusion Protein Ag1859 (543-892 aa encoded by BC015766)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EIQGLTTAH EQFKATLPDA DKERLAILGI HNEVSKIVQT YHVNMAGTNP YTTITPQEIN GKWDHVRQLV PRRDQALTEE HARQQHNERL RKQFGAQANV IGPWIQTKME EIGRISIEMH GTLEDQLSHL RQYEKSIVNY KPKIDQLEGD HQLIQEALIF DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMNEF RASFNHFDRD HSGTLGPEEF KACLISLGYD IGNDPQGEAE FARIMSIVDP NRLGVVTFQA FIDFMSRETA DTDTADQVMA SFKILAGDKN YITMDELRRE LPPDQAEYCI ARMAPYTGPD SVPGALDYMS FSTALYGESD L (543-892 aa encoded by BC015766)
Target Information
Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actinin 1 smooth muscle; alpha actinin 1a; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; epididymis secretory sperm binding protein; F-actin cross-linking protein; FLJ40884; FLJ54432; non-muscle alpha-actinin 1; Non-muscle alpha-actinin-1; unnamed protein product
Gene Aliases: 3110023F10Rik; ACTN1; Actn1a; BDPLT15
UniProt ID: (Human) P12814, (Rat) Q9Z1P2, (Mouse) Q7TPR4
Entrez Gene ID: (Human) 87, (Rat) 81634, (Mouse) 109711
transcription coactivator activity
double-stranded RNA binding
actin binding
integrin binding
calcium ion binding
protein binding
cytoskeletal protein binding
vinculin binding
identical protein binding
protein homodimerization activity
ion channel binding
metal ion binding
actin filament binding
structural constituent of postsynapse
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity
focal adhesion assembly
actin filament bundle assembly
negative regulation of cellular component movement
actin crosslink formation
regulation of nucleic acid-templated transcription
cortical cytoskeleton organization
actin filament organization
actin cytoskeleton organization
platelet activation
platelet formation
platelet morphogenesis
regulation of apoptotic process
positive regulation of transcription, DNA-templated
anatomical structure formation involved in morphogenesis
actin filament network formation
muscle cell development
platelet aggregation
postsynapse organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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