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Proteintech
Human IgA Heavy Chain Polyclonal Antibody
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Product Details
11449-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human IgA Heavy Chain Fusion Protein Ag2007 (4-353 aa encoded by BC016369)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes the Chain C region of human Ig alpha-1 (IGHA1).
Immunogen sequence: TSPKVFPLS LCSTQPDGNV VIACLVQGFF PQEPLSVTWS ESGQGVTARN FPPSQDASGD LYTTSSQLTL PATQCLAGKS VTCHVKHYTN PSQDVTVPCP VPSTPPTPSP STPPTPSPSC CHPRLSLHRP ALEDLLLGSE ANLTCTLTGL RDASGVTFTW TPSSGKSAVQ GPPERDLCGC YSVSSVLPGC AEPWNHGKTF TCTAAYPESK TPLTATLSKS GNTFRPEVHL LPPPSEELAL NELVTLTCLA RGFSPKDVLV RWLQGSQELP REKYLTWASR QEPSQGTTTF AVTSILRVAA EDWKKGDTFS CMVGHEALPL AFTQKTIDRL AGKPTHVNVS VVMAEVDGTC Y (4-353 aa encoded by BC016369)
Target Information
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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