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Proteintech
HSD17B6 Polyclonal Antibody
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Product Details
11855-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HSD17B6 Fusion Protein Ag2427 (1-317 aa encoded by BC020710)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MWLYLAAFV GLYYLLHWYR ERQVVSHLQD KYVFITGCDS GFGNLLARQL DARGLRVLAA CLTEKGAEQL RGQTSDRLET VTLDVTKMES IAAATQWVKE HVGDRGLWGL VNNAGILTPI TLCEWLNTED SMNMLKVNLI GVIQVTLSML PLVRRARGRI VNVSSILGRV AFFVGGYCVS KYGVEAFSDI LRREIQHFGV KISIVEPGYF RTGMTNMTQS LERMKQSWKE APKHIKETYG QQYFDALYNI MKEGLLNCST NLNLVTDCME HALTSVHPRT RYSAGWDAKF FFIPLSYLPT SLADYILTRS WPKPAQAV (1-317 aa encoded by BC020710)
Target Information
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 17-beta-HSD 6; 17-beta-HSD6; 17-beta-HSD9; 17-beta-hydroxysteroid dehydrogenase type 6; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; 3-hydroxysteroid epimerase; hydroxysteroid (17-beta) dehydrogenase 6 homolog; hydroxysteroid (17-beta) dehydrogenase 9; hydroxysteroid 17-beta dehydrogenase 9; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase; oxidative 17 beta hydroxysteroid dehydrogenase type 6; Oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; oxidoreductase; retinol dehydrogenase; Short chain dehydrogenase/reductase family 9C member 6; unnamed protein product
Gene Aliases: 17betaHSD9; Gm182; HSD17B6; Hsd17b9; HSE; Rdh8; RODH; SDR9C6
UniProt ID: (Human) O14756, (Rat) O54753, (Mouse) Q9R092
Entrez Gene ID: (Human) 8630, (Rat) 286964, (Mouse) 27400
catalytic activity
estradiol 17-beta-dehydrogenase activity
retinol dehydrogenase activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
androsterone dehydrogenase activity
5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
testosterone dehydrogenase (NAD+) activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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