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Proteintech
Angiotensinogen Polyclonal Antibody
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Product Details
11992-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Angiotensinogen Fusion Protein Ag2632 (136-485 aa encoded by BC011519)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PTAVFGTLA SLYLGALDHT ADRLQAILGV PWKDKNCTSR LDAHKVLSAL QAVQGLLVAQ GRADSQAQLL LSTVVGVFTA PGLHLKQPFV QGLALYTPVV LPRSLDFTEL DVAAEKIDRF MQAVTGWKTG CSLTGASVDS TLAFNTYVHF QGKMKGFSLL AEPQEFWVDN STSVSVPMLS GMGTFQHWSD IQDNFSVTQV SFTESACLLL IQPHYASDLD KVEGLTFQQN SLNWMKKLSP RTIHLTMPQL VLQGSYDLQD LLAQAELPAI LHTELNLQKL SNDRIRVGEV LNSIFFELEA DEREPTESTQ QLNKPEVLEV TLNRPFLFAV YDQSATALHF LGRVANPLST A (136-485 aa encoded by BC011519)
Target Information
The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; fetal-liver predominant transporter 1; pre-angiotensinogen; preangiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8; unnamed protein product
Gene Aliases: AGT; ANHU; hFLT1; SERPINA8
UniProt ID: (Human) P01019
Entrez Gene ID: (Human) 183
regulation of cell growth
positive regulation of cytokine production
kidney development
blood vessel remodeling
regulation of blood volume by renin-angiotensin
renin-angiotensin regulation of aldosterone production
regulation of renal output by angiotensin
regulation of blood vessel size by renin-angiotensin
renal system process
regulation of systemic arterial blood pressure by renin-angiotensin
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
phospholipase C-activating G-protein coupled receptor signaling pathway
cell-cell signaling
regulation of blood pressure
positive regulation of endothelial cell migration
positive regulation of cardiac muscle hypertrophy
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of macrophage derived foam cell differentiation
response to muscle activity involved in regulation of muscle adaptation
regulation of vasoconstriction
positive regulation of superoxide anion generation
low-density lipoprotein particle remodeling
regulation of renal sodium excretion
nitric oxide-cGMP-mediated signaling pathway
angiotensin-activated signaling pathway
regulation of cell proliferation
vasoconstriction
regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAP kinase activity
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of fibroblast proliferation
positive regulation of inflammatory response
negative regulation of neurotrophin TRK receptor signaling pathway
positive regulation of protein kinase B signaling
renal sodium ion absorption
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of cholesterol metabolic process
regulation of blood vessel diameter
positive regulation of angiotensin-activated signaling pathway
regulation of extracellular matrix assembly
positive regulation of extracellular matrix assembly
negative regulation of sodium ion transmembrane transport
positive regulation of membrane hyperpolarization
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of gap junction assembly
regulation of cardiac conduction
response to angiotensin
positive regulation of reactive oxygen species metabolic process
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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