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Proteintech
LYNX1 Polyclonal Antibody
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Product Details
13373-1-AP
Product Specifications
Species Reactivity
Rat,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LYNX1 Fusion Protein Ag4195 (21-131 aa encoded by BC032306)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LDCHVCAYN GDNCFNPMRC PAMVAYCMTT RTSAAEAIWC HQCTGFGGCS HGSRCLRDST HCVTTATRVL SNTEDLPLVT KMCHIGCPDI PSLGLGPYVS IACCQTSLCN HD (21-131 aa encoded by BC032306)
Target Information
LYNX1 acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR. In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs. Prevents plasticity in the primary visual cortex late in life.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endogenous prototoxin LYNX1; GC26; Ly-6 neurotoxin-like protein 1; Ly-6/neurotoxin-like protein 1; secreted Ly-6/uPAR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2; Testicular tissue protein Li 112
Gene Aliases: AI838844; LYNX1; SLURP-2
UniProt ID: (Human) P0DP58, (Mouse) P0DP60
Entrez Gene ID: (Human) 66004, (Mouse) 23936, (Rat) 300018
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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