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Proteintech
TBX21/T-bet Polyclonal Antibody
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Product Details
13700-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TBX21,T-bet Fusion Protein Ag4618 (1-328 aa encoded by BC039739)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGIVEPGCG DMLTGTEPMP GSDEGRAPGA DPQHRYFYPE PGAQDADERR GGGSLGSPYP GGALVPAPPS RFLGAYAYPP RPQAAGFPGA GESFPPPADA EGYQPGEGYA APDPRAGLYP GPREDYALPA GLEVSGKLRV ALNNHLLWSK FNQHQTEMII TKQGRRMFPF LSFTVAGLEP TSHYRMFVDV VLVDQHHWRY QSGKWVQCGK AEGSMPGNRL YVHPDSPNTG AHWMRQEVSF GKLKLTNNKG ASNNVTQMIV LQSLHKYQPR LHIVEVNDGE PEAACNASNT HIFTFQETQF IAVTAYQNAE ITQLKIDNNP FAKGFRENF (1-328 aa encoded by BC039739 )
Target Information
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HGNC:11599; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor expressed in T cells; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
Gene Aliases: IMD88; T-bet; T-PET; TBET; TBLYM; TBT1; TBX21
UniProt ID: (Human) Q9UL17, (Mouse) Q9JKD8
Entrez Gene ID: (Human) 30009, (Mouse) 57765
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcription regulatory region DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell fate specification
T-helper 1 cell lineage commitment
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to virus
positive regulation of gene expression
T cell differentiation
negative regulation of interleukin-2 production
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of isotype switching to IgG isotypes
regulation of immune response
lymphocyte migration
negative regulation of T-helper 17 cell differentiation
negative regulation of T-helper 17 cell lineage commitment
negative regulation of T-helper 2 cell cytokine production
positive regulation of T-helper 1 cell cytokine production
transcription, DNA-templated
cellular response to organic substance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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