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Proteintech
PKC iota Polyclonal Antibody
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Product Details
13883-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Chicken,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PKC iota Fusion Protein Ag4990 (238-587 aa encoded by BC022016)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSLGLQDFD LLRVIGRGSY AKVLLVRLKK TDRIYAMKVV KKELVNDDED IDWVQTEKHV FEQASNHPFL VGLHSCFQTE SRLFFVIEYV NGGDLMFHMQ RQRKLPEEHA RFYSAEISLA LNYLHERGII YRDLKLDNVL LDSEGHIKLT DYGMCKEGLR PGDTTSTFCG TPNYIAPEIL RGEDYGFSVD WWALGVLMFE MMAGRSPFDI VGSSDNPDQN TEDYLFQVIL EKQIRIPRSM SVKAASVLKS FLNKDPKERL GCLPQTGFAD IQGHPFFRNV DWDMMEQKQV VPPFKPNISG EFGLDNFDSQ FTNERVQLTP DDDDIVRKID QSEFEGFEYI NPLLMSAEEC V (238-587 aa encoded by BC022016)
Target Information
The PKC family of serine/threonine kinases, including PRKCI (PKC iota), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; nPKC-iota; PRKC-lambda/iota; Protein kinase C iota type; unnamed protein product
Gene Aliases: DXS1179E; nPKC-iota; PKCI; PRKCI
UniProt ID: (Human) P41743
Entrez Gene ID: (Human) 5584
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-independent protein kinase C activity
protein binding
ATP binding
phospholipid binding
zinc ion binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
protein phosphorylation
protein targeting to membrane
cytoskeleton organization
actin filament organization
positive regulation of neuron projection development
vesicle-mediated transport
cell migration
establishment of cell polarity
cellular response to insulin stimulus
negative regulation of glial cell apoptotic process
establishment of apical/basal cell polarity
intracellular signal transduction
eye photoreceptor cell development
negative regulation of apoptotic process
response to peptide hormone
negative regulation of neuron apoptotic process
establishment or maintenance of epithelial cell apical/basal polarity
cell-cell junction organization
positive regulation of Notch signaling pathway
positive regulation of glucose import
secretion
Golgi vesicle budding
positive regulation of NF-kappaB transcription factor activity
positive regulation of glial cell proliferation
membrane organization
cellular response to chemical stress
response to interleukin-1
protein localization to plasma membrane
regulation of postsynaptic membrane neurotransmitter receptor levels
positive regulation of protein localization to plasma membrane
positive regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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