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Proteintech
ACSL1 Polyclonal Antibody
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Product Details
13989-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACSL1 Fusion Protein Ag5059 (349-698 aa encoded by BC050073)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
An anti-rat ACSL1 antibody recognized a band of the predicted 68 kDa in high-speed supernatant from rat liver and in human and murine SMCs, monocyte-derived macrophages, and murine peritoneal macrophages. It has 2 isoforms produced by alternative splicing.
Immunogen sequence: RLLMDDLKV LQPTVFPVVP RLLNRMFDRI FGQANTTLKR WLLDFASKRK EAELRSGIIR NNSLWDRLIF HKVQSSLGGR VRLMVTGAAP VSATVLTFLR AALGCQFYEG YGQTECTAGC CLTMPGDWTA GHVGAPMPCN LIKLVDVEEM NYMAAEGEGE VCVKGPNVFQ GYLKDPAKTA EALDKDGWLH TGDIGKWLPN GTLKIIDRKK HIFKLAQGEY IAPEKIENIY MRSEPVAQVF VHGESLQAFL IAIVVPDVET LCSWAQKRGF EGSFEELCRN KDVKKAILED MVRLGKDSGL KPFEQVKGIT LHPELFSIDN GLLTPTMKAK RPELRNYFRS QIDDLYSTIK V (349-698 aa encoded by BC050073)
Target Information
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ACS1; ACSL1 isoform a; ACSL1 isoform c; Acyl CoA synthetase, long chain; Acyl-CoA synthetase 1; Arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 2; fatty-acid-Coenzyme A ligase, long-chain 1; fatty-acid-Coenzyme A ligase, long-chain 2; L LACS2; LACS 1; LACS 2; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 1; Long-chain acyl-CoA synthetase 2; Long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; Long-chain-fatty-acid--CoA ligase 1; Long-chain-fatty-acid--CoA ligase, liver isozyme; OTTHUMP00000218457; OTTHUMP00000218460; OTTHUMP00000218462; OTTHUMP00000218465; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1; Phytanate--CoA ligase; unnamed protein product
Gene Aliases: Acas; Acas1; ACS; ACS1; ACSL1; Acsl2; COAA; FACL1; FACL2; FACS; LACS; LACS 1; LACS1; LACS2
UniProt ID: (Human) P33121, (Mouse) P41216, (Rat) P18163
Entrez Gene ID: (Human) 2180, (Mouse) 14081, (Rat) 25288
nucleotide binding
long-chain fatty acid-CoA ligase activity
ATP binding
ligase activity
protein serine/threonine kinase activator activity
arachidonate-CoA ligase activity
phytanate-CoA ligase activity
pristanate-CoA ligase activity
palmitoyl-CoA ligase activity
oleoyl-CoA ligase activity
acetate-CoA ligase activity
ligase
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
response to nutrient
lipid biosynthetic process
response to xenobiotic stimulus
positive regulation of plasma membrane long-chain fatty acid transport
fatty acid transport
triglyceride biosynthetic process
adiponectin-activated signaling pathway
response to oleic acid
long-chain fatty-acyl-CoA biosynthetic process
xenobiotic catabolic process
linoleic acid metabolic process
long-chain fatty acid import
positive regulation of cold-induced thermogenesis
triglyceride metabolic process
response to organic substance
response to organic cyclic compound
response to drug
positive regulation of protein serine/threonine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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