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Proteintech
TRIM24 Polyclonal Antibody
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Product Details
14208-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRIM24 Fusion Protein Ag5417 (701-1050 aa encoded by BC028689)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SKPAGADST HKVPVVMLEP IRIKQENSGP PENYDFPVVI VKQESDEESR PQNANYPRSI LTSLLLNSSQ SSTSEETVLR SDAPDSTGDQ PGLHQDNSSN GKSEWLDPSQ KSPLHVGETR KEDDPNEDWC AVCQNGGELL CCEKCPKVFH LSCHVPTLTN FPSGEWICTF CRDLSKPEVE YDCDAPSHNS EKKKTEGLVK LTPIDKRKCE RLLLFLYCHE MSLAFQDPVP LTVPDYYKII KNPMDLSTIK KRLQEDYSMY SKPEDFVADF RLIFQNCAEF NEPDSEVANA GIKLENYFEE LLKNLYPEKR FPKPEFRNES EDNKFSDDSD DDFVQPRKKR LKSIEERQLL K (701-1050 aa encoded by BC028689)
Target Information
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ab2-427; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; transcriptional intermediary factor 1, alpha; Tripartite motif-containing protein 24; unnamed protein product
Gene Aliases: A130082H20Rik; AI447469; D430004I05Rik; hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1-alpha; TIF1A; TIF1ALPHA; TRIM24
UniProt ID: (Human) O15164, (Mouse) Q64127
Entrez Gene ID: (Human) 8805, (Rat) 500084, (Mouse) 21848
p53 binding
DNA binding
chromatin binding
transcription coactivator activity
protein kinase activity
ubiquitin-protein transferase activity
receptor binding
protein binding
zinc ion binding
transferase activity
ligand-dependent nuclear receptor binding
estrogen response element binding
sequence-specific DNA binding
metal ion binding
ubiquitin protein ligase activity
histone H3K23ac reader activity
molecular_function
methylated histone binding
lysine-acetylated histone binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
chromatin/chromatin-binding, or -regulatory protein
chromatin organization
transcription from RNA polymerase II promoter
positive regulation of gene expression
protein ubiquitination
protein catabolic process
regulation of protein stability
regulation of apoptotic process
response to peptide hormone
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
epithelial cell proliferation
negative regulation of epithelial cell proliferation
calcium ion homeostasis
regulation of vitamin D receptor signaling pathway
cellular response to estrogen stimulus
regulation of signal transduction by p53 class mediator
protein phosphorylation
negative regulation of cell proliferation
protein autophosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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