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Proteintech
MT1-MMP Polyclonal Antibody
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Product Details
14552-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MT1-MMP Fusion Protein Ag5965 (1-350 aa encoded by BC064803)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSPAPRPSR CLLLPLLTLG TALASLGSAQ SSSFSPEAWL QQYGYLPPGD LRTHTQRSPQ SLSAAIAAMQ KFYGLQVTGK ADADTMKAMR RPRCGVPDKF GAEIKANVRR KRYAIQGLKW QHNEITFCIQ NYTPKVGEYA TYEAIRKAFR VWESATPLRF REVPYAYIRE GHEKQADIMI FFAEGFHGDS TPFDGEGGFL AHAYFPGPNI GGDTHFDSAE PWTVRNEDLN GNDIFLVAVH ELGHALGLEH SSDPSAIMAP FYQWMDTENF VLPDDDRRGI QQLYGGESGF PTKMPPQPRT TSRPSVPDKP KNPTYGPNIC DGNFDTVAML RGEMFVFKER WFWRVRNNQV M (1-350 aa encoded by BC064803)
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; Matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase; Membrane type 1-MMP; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP; MMP-14; MMP-X MT-MMP; MMP-X1; MMPs; MT-MMP; MT-MMP 1; MT-MMP MT1-MMP; MT1-MMP; MT1MMP; MTMMP1; type 1 matrix metalloprotease 14; unnamed protein product
Gene Aliases: AI325305; MMP-14; MMP-X1; MMP14; MT-MMP; MT-MMP 1; MT-MMP-1; MT1-MMP; MT1MMP; Mtmmp; MTMMP1; sabe; WNCHRS
UniProt ID: (Human) P50281, (Mouse) P53690, (Rat) Q10739
Entrez Gene ID: (Human) 4323, (Mouse) 17387, (Rat) 81707
endopeptidase activity
metalloendopeptidase activity
serine-type endopeptidase activity
integrin binding
protein binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
metal ion binding
metalloaminopeptidase activity
transcription factor activity, sequence-specific DNA binding
calcium ion binding
peptidase activator activity
metalloprotease
skeletal system development
ossification
angiogenesis
ovarian follicle development
response to hypoxia
endothelial cell proliferation
endochondral ossification
proteolysis
response to oxidative stress
male gonad development
response to mechanical stimulus
anatomical structure morphogenesis
response to hormone
positive regulation of myotube differentiation
positive regulation of protein processing
cell migration
protein processing
extracellular matrix disassembly
protein catabolic process
extracellular matrix organization
positive regulation of cell growth
lung development
positive regulation of cell migration
collagen catabolic process
zymogen activation
endodermal cell differentiation
chondrocyte proliferation
astrocyte cell migration
response to estrogen
positive regulation of B cell differentiation
negative regulation of Notch signaling pathway
embryonic cranial skeleton morphogenesis
branching morphogenesis of an epithelial tube
tissue remodeling
cell motility
negative regulation of focal adhesion assembly
head development
bone development
cellular response to genistein
craniofacial suture morphogenesis
GDF15-GFRAL signaling pathway
negative regulation of GDF15-GFRAL signaling pathway
regulation of protein localization to plasma membrane
positive regulation of macrophage migration
response to odorant
regulation of transcription, DNA-templated
positive regulation of peptidase activity
response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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