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Proteintech
UCHL1/PGP9.5 Polyclonal Antibody
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Product Details
14730-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UCHL1/PGP9.5 Fusion Protein Ag6490 (1-223 aa encoded by BC000332)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MQLKPMEIN PEMLNKVLSR LGVAGQWRFV DVLGLEEESL GSVPAPACAL LLLFPLTAQH ENFRKKQIEE LKGQEVSPKV YFMKQTIGNS CGTIGLIHAV ANNQDKLGFE DGSVLKQFLS ETEKMSPEDR AKCFEKNEAI QAAHDAVAQE GQCRVDDKVN FHFILFNNVD GHLYELDGRM PFPVNHGASS EDTLLKDAAK VCREFTEREQ GEVRFSAVAL CKAA (1-223 aa encoded by BC000332)
Target Information
PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis luminal protein 117; epididymis secretory protein Li 53; gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; PGP 9.5; PGP9.5; protein gene product 9.5; ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; ubiquitin thiolesterase; UCH-L1; UCHL
Gene Aliases: AW822034; C88048; gad; HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; R75593; UCH-L1; UCHL-1; UCHL1
UniProt ID: (Human) P09936, (Mouse) Q9R0P9, (Rat) Q00981
Entrez Gene ID: (Human) 7345, (Mouse) 22223, (Rat) 29545
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
omega peptidase activity
ligase activity
ubiquitin protein ligase binding
alpha-2A adrenergic receptor binding
ubiquitin binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
cysteine protease
response to ischemia
axon target recognition
adult walking behavior
cell proliferation
regulation of macroautophagy
protein deubiquitination
sensory perception of pain
axonal transport of mitochondrion
eating behavior
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAP kinase activity
muscle fiber development
neuromuscular process
proteolysis
ubiquitin-dependent protein catabolic process
axonogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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