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Proteintech
MECR Polyclonal Antibody
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Product Details
14932-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MECR Fusion Protein Ag6738 (1-373 aa encoded by BC001419)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MWVCSTLWR VRTPARQWRG LLPASGCHGP AASSYSASAE PARVRALVYG HHGDPAKVVE LKNLELAAVR GSDVRVKMLA APINPSDINM IQGNYGLLPE LPAVGGNEGV AQVVAVGSNV TGLKPGDWVI PANAGLGTWR TEAVFSEEAL IQVPSDIPLQ SAATLGVNPC TAYRMLMDFE QLQPGDSVIQ NASNSGVGQA VIQIAAALGL RTINVVRDRP DIQKLSDRLK SLGAEHVITE EELRRPEMKN FFKDMPQPRL ALNCVGGKSS TELLRQLARG GTMVTYGGMA KQPVVASVSL LIFKDLKLRG FWLSQWKKDH SPDQFKELIL TLCDLIRRGQ LTAPACSQVP LQDYQSALEA SMKPFISSKQ ILTM (1-373 aa encoded by BC001419)
Target Information
The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-enoyl thioester reductase; CGI-63; Enoyl-[acyl-carrier-protein] reductase, mitochondrial; homolog of yeast 2-enoyl thioester reductase; HsNrbf-1; mitochondrial 2-enoyl thioester reductase; NRBF-1; nuclear receptor binding factor 1; Nuclear receptor-binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial; unnamed protein product
Gene Aliases: AI195831; CGI-63; DYTOABG; ETR1; FASN2B; MECR; NBRF1; NRBF1; OPA16
UniProt ID: (Human) Q9BV79, (Mouse) Q9DCS3, (Rat) Q9Z311
Entrez Gene ID: (Human) 51102, (Mouse) 26922, (Rat) 29470
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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