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Proteintech

beta Arrestin 1 Polyclonal Antibody

15 References
View all (33) beta Arrestin 1 antibodies

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beta Arrestin 1 Polyclonal Antibody

Product Details

15361-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

beta Arrestin 1 Fusion Protein Ag7608 (69-418 aa encoded by BC003636)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Amount

19.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DVLGLTFRK DLFVANVQSF PPAPEDKKPL TRLQERLIKK LGEHAYPFTF EIPPNLPCSV TLQPGPEDTG KACGVDYEVK AFCAENLEEK IHKRNSVRLV IRKVQYAPER PGPQPTAETT RQFLMSDKPL HLEASLDKEI YYHGEPISVN VHVTNNTNKT VKKIKISVRQ YADICLFNTA QYKCPVAMEE ADDTVAPSST FCKVYTLTPF LANNREKRGL ALDGKLKHED TNLASSTLLR EGANREILGI IVSYKVKVKL VVSRGGLLGD LASSDVAVEL PFTLMHPKPK EEPPHREVPE NETPVDTNLI ELDTNDDDIV FEDFARQRLK GMKDDKEEEE DGTGSPQLNN R (69-418 aa encoded by BC003636)

Target Information

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: arrestin; arrestin 2; Arrestin beta-1; beta-arrestin; Beta-arrestin-1; beta-arrestin1; Non-visual arrestin-2; unnamed protein product

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Gene Aliases: 1200006I17Rik; ARB1; ARR1; ARRB1; AW208571; BARRES; G430100A01Rik

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UniProt ID: (Human) P49407, (Rat) P29066, (Mouse) Q8BWG8

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Entrez Gene ID: (Human) 408, (Rat) 25387, (Mouse) 109689

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Function(s)
G-protein coupled receptor binding transcription coactivator activity histone acetyltransferase activity enzyme inhibitor activity GTPase activator activity insulin-like growth factor receptor binding protein binding enzyme binding ubiquitin protein ligase binding angiotensin receptor binding binding, bridging arrestin family protein binding transcription factor binding clathrin binding estrogen receptor binding mitogen-activated protein kinase kinase binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding follicle-stimulating hormone receptor binding V2 vasopressin receptor binding AP-2 adaptor complex binding clathrin adaptor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process transcription regulatory region DNA binding ion channel binding protein phosphorylated amino acid binding phosphoprotein binding scaffold/adaptor protein
Process(es)
positive regulation of protein phosphorylation desensitization of G-protein coupled receptor protein signaling pathway G-protein coupled receptor internalization positive regulation of receptor internalization regulation of transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process signal transduction sensory perception negative regulation of signal transduction positive regulation of cardiac muscle hypertrophy protein transport protein ubiquitination negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of Rho protein signal transduction stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of ERK1 and ERK2 cascade positive regulation of intracellular signal transduction activation of MAPK activity negative regulation of protein phosphorylation desensitization of G-protein coupled receptor protein signaling pathway by arrestin transcription from RNA polymerase II promoter endocytosis receptor-mediated endocytosis G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway phototransduction regulation of G-protein coupled receptor protein signaling pathway sensory perception of pain regulation of cAMP biosynthetic process regulation of cAMP catabolic process positive regulation of protein ubiquitination positive regulation of protein binding positive regulation of peptidyl-serine phosphorylation negative regulation of GTPase activity positive regulation of smooth muscle cell apoptotic process positive regulation of histone acetylation positive regulation of insulin secretion involved in cellular response to glucose stimulus follicle-stimulating hormone signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of GTPase activity sensory perception of touch negative regulation of ERK1 and ERK2 cascade positive regulation of histone H4 acetylation transcription, DNA-templated regulation of transcription, DNA-templated transport
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