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Proteintech
Pyruvate Carboxylase Polyclonal Antibody
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FIGURE: 1 / 12
Pyruvate Carboxylase Antibody (16588-1-AP) in ICC/IF
Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using (Product # 16588-1-AP) (Pyruvate Carboxylase antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). F-actin is stained using CL555-phalloidin (red) and DNA is stained by DAPI (blue).
Product Details
16588-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Pyruvate Carboxylase Fusion Protein Ag8857 (828-1178 aa encoded by BC011617)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERVFDYSE YWEGARGLYA AFDCTATMKS GNSDVYENEI PGGQYTNLHF QAHSMGLGSK FKEVKKAYVE ANQMLGDLIK VTPSSKIVGD LAQFMVQNGL SRAEAEAQAE ELSFPRSVVE FLQGYIGVPH GGFPEPFRSK VLKDLPRVEG RPGASLPPLD LQALEKELVD RHGEEVTPED VLSAAMYPDV FAHFKDFTAT FGPLDSLNTR LFLQGPKIAE EFEVELERGK TLHIKALAVS DLNRAGQRQV FFELNGQLRS ILVKDTQAMK EMHFHPKALK DVKGQIGAPM PGKVIDIKVV AGAKVAKGQP LCVLSAMKME TVVTSPMEGT VRKVHVTKDM TLEGDDLILE IE (828-1178 aa encoded by BC011617)
Target Information
Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 6.4.1.1; PCB; PYC; pyruvate carboxylase; Pyruvate carboxylase, mitochondrial; pyruvate decarboxylase; Pyruvic carboxylase; unnamed protein product
Gene Aliases: PC; PCB; Pcx
UniProt ID: (Human) P11498, (Rat) P52873
Entrez Gene ID: (Human) 5091, (Rat) 25104, (Mouse) 18563
gluconeogenesis
lipid metabolic process
NADP metabolic process
negative regulation of gene expression
viral RNA genome packaging
viral release from host cell
NAD metabolic process
small molecule metabolic process
positive regulation by host of viral process
pyruvate metabolic process
oxaloacetate metabolic process
positive regulation by host of viral release from host cell
metabolic process
positive regulation of phospholipid biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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