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Proteintech
ATP6V1A Polyclonal Antibody
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Product Details
17115-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP6V1A Fusion Protein Ag10801 (268-617 aa encoded by BC013138)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NSDVIIYVG CGERGNEMSE VLRDFPELTM EVDGKVESIM KRTALVANTS NMPVAAREAS IYTGITLSEY FRDMGYHVSM MADSTSRWAE ALREISGRLA EMPADSGYPA YLGARLASFY ERAGRVKCLG NPEREGSVSI VGAVSPPGGD FSDPVTSATL GIVQVFWGLD KKLAQRKHFP SVNWLISYSK YMRALDEYYD KHFTEFVPLR TKAKEILQEE EDLAEIVQLV GKASLAETDK ITLEVAKLIK DDFLQQNGYT PYDRFCPFYK TVGMLSNMIA FYDMARRAVE TTAQSDNKIT WSIIREHMGD ILYKLSSMKF KDPLKDGEAK IKSDYAQLLE DMQNAFRSLE D (268-617 aa encoded by BC013138)
Target Information
ATP6V1A encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 70-kDa subunit; ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, isoform 2; ATPase, H+ transporting, lysosomal 70kD, V1 subunit A, isoform 1; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; ATPase, H+ transporting, lysosomal, subunit A1; ATPase, H+ transporting, V1 subunit A, isoform 1; ATPase, H+ transporting, V1 subunit A1; H(+)-transporting two-sector ATPase, subunit A; H+-transporting ATPase chain A, vacuolar (VA68 type); lysosomal 70kDa; unnamed protein product; V-ATPase 69 kDa subunit; V-ATPase 69 kDa subunit 1; V-ATPase A subunit 1; V-ATPase subunit A; V-type proton ATPase (V-ATPase) catalytic subunit A; V-type proton ATPase catalytic subunit A; Vacuolar ATPase isoform VA68; vacuolar proton pump alpha subunit 1; Vacuolar proton pump subunit alpha; vacuolar-type H(+)-ATPase
Gene Aliases: AI647066; ARCL2D; ATP6A1; Atp6a2; ATP6V1A; ATP6V1A1; DEE93; HO68; IECEE3; VA68; Vma1; VPP2
UniProt ID: (Human) P38606, (Mouse) P50516
Entrez Gene ID: (Human) 523, (Mouse) 11964, (Rat) 685232
ion transport
cellular iron ion homeostasis
vacuolar acidification
lysosomal lumen acidification
regulation of macroautophagy
cellular response to increased oxygen levels
homeostatic process
ATP metabolic process
endosomal lumen acidification
intracellular pH reduction
Golgi lumen acidification
synaptic vesicle lumen acidification
hydrogen ion transmembrane transport
transport
ATP hydrolysis coupled proton transport
proton transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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