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Proteintech
EIF2AK2/PKR Polyclonal Antibody
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Product Details
18244-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EIF2AK2, PKR Fusion Protein Ag13010 (1-373 aa encoded by BC093676)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to EIF2AK2.
Immunogen sequence: MAGDLSAGF FMEELNTYRQ KQGVVLKYQE LPNSGPPHDR RFTFQVIIDG REFPEGEGRS KKEAKNAAAK LAVEILNKEK KAVSPLLLTT TNSSEGLSMG NYIGLINRIA QKKRLTVNYE QCASGVHGPE GFHYKCKMGQ KEYSIGTGST KQEAKQLAAK LAYLQILSEE TSVKSDYLSS GSFATTCESQ SNSLVTSTLA SESSSEGDFS ADTSEINSNS DSLNSSSLLM NGLRNNQRKA KRSLAPRFDL PDMKETKYTV DKRFGMDFKE IELIGSGGFG QVFKAKHRID GKTYVIKRVK YNNEKAEREV KALAKLDHVN IVHYNGCWDG FDYDPETSDD SLESSDYDPE NSKNSSRSKT KCLFIQMEFC DKGT (1-373 aa encoded by BC093676)
Target Information
EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & malignancy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF-2A protein kinase 2; eIF2a Kinase; eukaryotic translation initiation factor 2 alpha kinase 2; Eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; Interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; Interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PRKR; protein kinase R; Protein kinase RNA-activated; protein kinase RNA-regulated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; Serine/threonine-protein kinase TIK; T-cell viral integration site; Tyrosine-protein kinase EIF2AK2; unnamed protein product
Gene Aliases: 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; DYT33; EIF2AK1; EIF2AK2; LEUDEN; PKR; PPP1R83; PRKR; Tik
UniProt ID: (Human) P19525, (Mouse) Q03963, (Rat) Q63184
Entrez Gene ID: (Human) 5610, (Mouse) 19106, (Rat) 54287
nucleotide binding
RNA binding
double-stranded RNA binding
protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein phosphatase regulator activity
identical protein binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
poly(A) RNA binding
non-receptor serine/threonine protein kinase
positive regulation of cytokine production
immune system process
translation
translational initiation
regulation of translational initiation
protein phosphorylation
negative regulation of cell proliferation
response to virus
negative regulation of translation
endoplasmic reticulum unfolded protein response
positive regulation of chemokine production
positive regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
cellular response to amino acid starvation
response to interferon-alpha
negative regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of viral genome replication
innate immune response
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
defense response to virus
antiviral innate immune response
regulation of NLRP3 inflammasome complex assembly
positive regulation of NIK/NF-kappaB signaling
regulation of hematopoietic progenitor cell differentiation
regulation of hematopoietic stem cell proliferation
regulation of hematopoietic stem cell differentiation
activation of MAPKK activity
transcription, DNA-templated
regulation of transcription, DNA-templated
response to toxic substance
phosphorylation
response to lipopolysaccharide
response to vitamin E
positive regulation of apoptotic process
response to mechanical stimulus
response to organic substance
peptidyl-tyrosine phosphorylation
response to exogenous dsRNA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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