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Proteintech
GABARAP Polyclonal Antibody
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Product Details
18723-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detected endogenous GABARAP protein in lysates from various tissues. It may cross-react with GABARAPL1 due to the high identity of amino acid sequence.
Target Information
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ25768; GABA(A) receptor-associated protein; GABA-A receptor-associated protein; GABARAP; GABARAP a; Gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid reseptor associated protein; MGC120154; MGC120155; MM46; unnamed protein product
Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46
UniProt ID: (Human) O95166, (Mouse) Q9DCD6
Entrez Gene ID: (Human) 11337, (Mouse) 56486
autophagosome assembly
microtubule cytoskeleton organization
mitophagy
protein targeting
autophagy
apoptotic process
cellular response to nitrogen starvation
chemical synaptic transmission
extrinsic apoptotic signaling pathway via death domain receptors
protein transport
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of Rac protein signal transduction
autophagosome maturation
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of protein K48-linked ubiquitination
mitophagy
transport
nucleophagy
membrane fusion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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