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NeoBiotechnologies
ELK1 Monoclonal Antibody (PCRP-ELK1-1B9)
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FIGURE: 1 / 2
ELK1 Antibody (2002-MSM1-P1ABX) in ARRAY
Analysis of Protein Array containing more than 19,000 full-length human proteins ELK1 Monoclonal Antibody (Product # 2002-MSM1-P1ABX). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in des... View More
Product Details
2002-MSM1-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
PCRP-ELK1-1B9
Immunogen
Recombinant full-length human ELK1 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is tested in direct ELISA.
Target Information
ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ELK 1; ELK1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene; unnamed protein product
Gene Aliases: ELK1
UniProt ID: (Human) P19419
Entrez Gene ID: (Human) 2002
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
mediator complex binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription regulator inhibitor activity
transcription regulator activator activity
sequence-specific double-stranded DNA binding
liver development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to light stimulus
gene expression
cell differentiation
lung development
response to ethanol
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to testosterone stimulus
cellular response to lipid
cellular response to gamma radiation
response to fibroblast growth factor
hippocampal neuron apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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