Search
Proteintech
RANKL Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
23408-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RANKL Fusion Protein Ag19975 (76-317 aa encoded by BC074890)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PNRISEDGT HCIYRILRLH ENADFQDTTL ESQDTKLIPD SCRRIKQAFQ GAVQKELQHI VGSQHIRAEK AMVDGSWLDL AKRSKLEAQP FAHLTINATD IPSGSHKVSL SSWYHDRGWA KISNMTFSNG KLIVNQDGFY YLYANICFRH HETSGDLATE YLQLMVYVTK TSIKIPSSHT LMKGGSTKYW SGNSEFHFYS INVGGFFKLR SGEEISIEVS NPSLLDPDQD ATYFGAFKVR DID (76-317 aa encoded by BC074890)
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD254; H-RANK-L; M-Rank-L; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; rank-l; RANKL; receptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; srankl; TNF-related activation-induced cytokine; TNF-related ligand; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; Tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11
Gene Aliases: CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNFSF11; TNLG6B; TRANCE
UniProt ID: (Human) O14788
Entrez Gene ID: (Human) 8600
negative regulation of transcription from RNA polymerase II promoter
ossification
osteoclast proliferation
monocyte chemotaxis
immune response
cell communication
cell surface receptor signaling pathway
JNK cascade
organ morphogenesis
positive regulation of gene expression
cytokine-mediated signaling pathway
calcium-mediated signaling
signaling
cell differentiation
osteoclast differentiation
tumor necrosis factor-mediated signaling pathway
mammary gland epithelial cell proliferation
positive regulation of homotypic cell-cell adhesion
osteoclast development
paracrine signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
protein kinase B signaling
tooth eruption
bone resorption
regulation of osteoclast differentiation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of T cell activation
positive regulation of corticotropin-releasing hormone secretion
positive regulation of protein kinase B signaling
calcium ion homeostasis
bone development
mammary gland alveolus development
positive regulation of ERK1 and ERK2 cascade
positive regulation of fever generation by positive regulation of prostaglandin secretion
positive regulation of NIK/NF-kappaB signaling
positive regulation of intracellular signal transduction
cellular response to leukemia inhibitory factor
positive regulation of osteoclast development
positive regulation of extrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support