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Glutathione S-Transferase Mu2 (GSTM2) Monoclonal Antibody (CPTC-GSTMu2-2)
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FIGURE: 1 / 5
Glutathione S-Transferase Mu2 (GSTM2) Antibody (2946-MSM1-P1) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of MeOH-fixed HeLa cells using Glutathione S-Transferase Mu2 (GSTM2) Monoclonal Antibody (Product # 2946-MSM1-P1) followed by goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red)..
Product Details
2946-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
CPTC-GSTMu2-2
Immunogen
Recombinant human full-length GSTMu2 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM2 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase M2; glutathione S-aryltransferase M2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-transferase M2 (muscle); Glutathione S-transferase Mu 2; glutathione S-transferase mu 2 (muscle); GST class-mu 2; GST, muscle; GSTM2-2; MGC117303; S-(hydroxyalkyl)glutathione lyase M2; unnamed protein product
Gene Aliases: GST4; GSTM; GSTM2; GSTM2-2; GTHMUS
UniProt ID: (Human) P28161
Entrez Gene ID: (Human) 2946
lipid metabolic process
glutathione metabolic process
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
nitrobenzene metabolic process
xenobiotic catabolic process
linoleic acid metabolic process
hepoxilin biosynthetic process
relaxation of cardiac muscle
cellular detoxification of nitrogen compound
cellular response to caffeine
cellular oxidant detoxification
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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