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NeoBiotechnologies
HSP90AB1 (Heat Shock Protein 90) Monoclonal Antibody (HSP90AB1, 3953)
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Product Details
3326-MSM3-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
HSP90AB1, 3953
Immunogen
Recombinant human HSP90AB1 protein fragment (around aa581-704)
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90kDa heat shock protein; Heat shock 84 kDa; heat shock 90kD protein 1, beta; Heat shock protein; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; HSP; HSP 84; HSP 90; HSP90-beta; RP1-302G2.1; unnamed protein product
Gene Aliases: D6S182; HSP84; HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB
UniProt ID: (Human) P08238
Entrez Gene ID: (Human) 3326
nucleotide binding
RNA binding
double-stranded RNA binding
protein binding
ATP binding
ATPase activity
protein kinase regulator activity
kinase binding
protein kinase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
heat shock protein binding
ubiquitin protein ligase binding
peptide binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
ATP-dependent protein binding
protein binding involved in protein folding
cadherin binding
protein dimerization activity
tau protein binding
unfolded protein binding
DNA polymerase binding
protein phosphatase activator activity
disordered domain specific binding
ATP-dependent protein folding chaperone
receptor ligand inhibitor activity
histone methyltransferase binding
placenta development
protein folding
response to unfolded protein
telomere maintenance via telomerase
virion attachment to host cell
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of protein ubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
cellular response to heat
negative regulation of apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
protein stabilization
chaperone-mediated protein complex assembly
regulation of cell cycle
cellular response to interleukin-4
fibril organization
negative regulation of proteasomal protein catabolic process
telomerase holoenzyme complex assembly
positive regulation of protein localization to cell surface
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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