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NeoBiotechnologies
Inhibin, alpha (INHA) Monoclonal Antibody (INHA, 4266)
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Product Details
3623-MSM6-P1ABX
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
INHA, 4266
Immunogen
A synthetic peptide (around aa73-96) of -alpha-subunit of human inhibin A protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A inhibin subunit; A-inhibin subunit; IHA; inhibin; inhibin A; inhibin A-subunit precursor; Inhibin alpha chain; inhibin alpha subunit
Gene Aliases: INHA
UniProt ID: (Human) P05111
Entrez Gene ID: (Human) 3623
skeletal system development
ovarian follicle development
signal transduction
cell surface receptor signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
cell-cell signaling
male gonad development
cell differentiation
erythrocyte differentiation
negative regulation of interferon-gamma production
regulation of cell proliferation
negative regulation of phosphorylation
hemoglobin biosynthetic process
negative regulation of B cell differentiation
negative regulation of macrophage differentiation
negative regulation of cell cycle
regulation of follicle-stimulating hormone secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
system development
negative regulation of multicellular organismal process
regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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