Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Cell Analysis
    • Antibodies
    • Mass Spectrometry
    • Cell Culture
    • Laboratory Instruments
    • Clinical and Diagnostics
    • Chromatography
    • Laboratory Equipment
    • Laboratory Supplies
    • Molecular Biology and Nucleic Acid Analysis
    • Sequence-Specific Nucleic Acid Products
    • See all product categories
  • Applications
    • Cell Culture and Transfection
    • Flow Cytometry
    • Cancer Research
    • Chromatography
    • Sequencing
    • PCR
    • Lab Solutions
    • Allergy Diagnostics
    • See all applications and techniques
  • Services
    • Cell Biology Services
    • Custom Services
    • Training Services
    • Lab Informatics Services
    • Financial and Leasing Services
    • Partnering and Licensing Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Food Safety Inspection Services
    • See all services
  • Help and Support
    • How to Order
    • Promotions and Online Offers
    • Contact Us
    • Change Location
    • Create a New Account
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Biotech
    • Biopharma
    • CDMO
    • Lab Diagnostics
    • Industrial and Applied Sciences
  • Special Offers
  • Contact Us
  • Quick Order
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Contact Us
          • Quick Order
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Custom Products & Projects
          • Primary Antibodies ›
          • Insulin Antibodies

          NeoBiotechnologies

          Insulin/IRDN Recombinant Rabbit Monoclonal Antibody (IRDN, 1980R)

          View all (60) Insulin antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support

          Cite Insulin/IRDN Recombinant Rabbit Monoclonal Antibody (IRDN, 1980R)

          Additional Information:
          {{banner.description}}
          {{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
          • Antibody Testing Data (2)
          Insulin/IRDN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Insulin/IRDN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          Insulin/IRDN Antibody (3630-RBM10-P1) in IHC (P)

          Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human pancreas using Insulin, IRDN Recombinant Monoclonal Antibody (Product # 3630-RBM10-P1). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          View Product

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          Insulin/IRDN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Insulin/IRDN Antibody in SDS-PAGE (SDS-PAGE)
          Insulin/IRDN Recombinant Rabbit Monoclonal Antibody (IRDN, 1980R)

          Product Details

          3630-RBM10-P1

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1-2 µg/mL
          -
          Product Specifications

          Species Reactivity

          Bovine, Human, Mouse, Pig, Rabbit

          Host/Isotype

          Rabbit / IgG

          Expression System

          HEK293 cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          IRDN, 1980R

          Immunogen

          Recombinant human full-length Insulin protein (IRDN)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          200 µg/mL

          Amount

          100 µg

          Purification

          Protein A/G

          Storage buffer

          PBS, pH 7.4, with 0.05% BSA

          Contains

          0.05% sodium azide

          Storage conditions

          4°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

          Target Information

          Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: Ins; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; Insulin; insulin splice variant; insulin variant; INS-splice; Insulin-1; Insulin-2; preproinsulin; proinsulin

          View more View less

          Gene Aliases: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; PNDM4; proinsulin

          View more View less

          UniProt ID: (Pig) P01315, (Human) P01308, (Mouse) P01325, (Mouse) P01326

          View more View less

          Entrez Gene ID: (Pig) 397415, (Bovine) 280829, (Rabbit) 100009181, (Human) 3630, (Mouse) 16333, (Mouse) 16334

          View more View less

          Function(s)
          protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity identical protein binding protein binding receptor agonist activity chaperone binding protein complex binding growth factor
          Process(es)
          negative regulation of acute inflammatory response glucose metabolic process regulation of cellular amino acid metabolic process acute-phase response G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway lipid biosynthetic process glycoprotein biosynthetic process positive regulation of nitric oxide mediated signal transduction positive regulation of glucose metabolic process positive regulation of phosphatidylinositol 3-kinase signaling lactate biosynthetic process regulation of transmembrane transporter activity positive regulation of cell migration positive regulation of protein autophosphorylation activation of protein kinase B activity negative regulation of NAD(P)H oxidase activity wound healing lipoprotein biosynthetic process negative regulation of protein catabolic process glucose homeostasis positive regulation of MAPK cascade negative regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of proteolysis negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipid catabolic process positive regulation of lipoprotein lipase activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of protein localization to nucleus positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process response to L-arginine neuron projection maintenance negative regulation of feeding behavior signal transduction feeding behavior protein secretion response to heat response to glucose positive regulation of gene expression response to nutrient levels positive regulation of insulin secretion response to food negative regulation of appetite positive regulation of mammary gland epithelial cell proliferation positive regulation of Rho protein signal transduction estradiol secretion negative regulation of apoptotic process glucose import in response to insulin stimulus positive regulation of protein secretion response to growth hormone positive regulation of peptide hormone secretion positive regulation of cell maturation negative regulation of lactation positive regulation of lactation positive regulation of blood circulation response to butyrate positive regulation of cytokine production regulation of transcription, DNA-templated cell-cell signaling negative regulation of gene expression positive regulation of neuron projection development positive regulation of cell growth regulation of protein localization nitric oxide-cGMP-mediated signaling pathway TORC1 signaling vasodilation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cell differentiation positive regulation of translation positive regulation of lipid biosynthetic process regulation of synaptic plasticity regulation of protein secretion cognition positive regulation of nitric-oxide synthase activity positive regulation of brown fat cell differentiation positive regulation of long-term synaptic potentiation cellular response to oxygen-containing compound negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process carbohydrate metabolic process glucose transport negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPK activity ER overload response activation of JUN kinase activity myoblast fusion regulation of gene expression myotube differentiation lipid catabolic process positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of phosphorylation regulation of protein binding positive regulation of phosphatidylinositol 3-kinase activity canonical Wnt signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Responsibility Responsibility
          • Trademarks
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Policy
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          México flag icon
          México

          Your items have has been added!


          Host server : magellan-search-blue-67655d8755-b2k9d:80/100.66.79.173:80.
          git-commit: dddaa802cd395f65bf1581942d0e97a089c38f41
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.46.0-Offline