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          • Primary Antibodies ›
          • Insulin Antibodies

          NeoBiotechnologies

          Insulin/IRDN Recombinant Rabbit Monoclonal Antibody (IRDN, 1980R)

          View all (60) Insulin antibodies

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          Cite Insulin/IRDN Recombinant Rabbit Monoclonal Antibody (IRDN, 1980R)

          Additional Information:
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          • Antibody Testing Data (2)
          Insulin/IRDN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Insulin/IRDN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          Insulin/IRDN Antibody (3630-RBM10-P1ABX) in IHC (P)

          Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human pancreas using Insulin, IRDN Recombinant Monoclonal Antibody (Product # 3630-RBM10-P1ABX). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Insulin/IRDN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Insulin/IRDN Antibody in SDS-PAGE (SDS-PAGE)
          Insulin/IRDN Recombinant Rabbit Monoclonal Antibody (IRDN, 1980R)

          Product Details

          3630-RBM10-P1ABX

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1-2 µg/mL
          -
          Product Specifications

          Species Reactivity

          Bovine, Human, Mouse, Pig, Rabbit

          Host/Isotype

          Rabbit / IgG

          Expression System

          HEK293 cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          IRDN, 1980R

          Immunogen

          Recombinant human full-length Insulin protein (IRDN)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A/G

          Storage buffer

          PBS, pH 7.4

          Contains

          no preservative

          Storage conditions

          -20°C or -80°C if preferred

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

          Target Information

          Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: Ins; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; Insulin; insulin splice variant; insulin variant; INS-splice; Insulin-1; Insulin-2; preproinsulin; proinsulin

          View more View less

          Gene Aliases: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; PNDM4; proinsulin

          View more View less

          UniProt ID: (Pig) P01315, (Human) P01308, (Mouse) P01325, (Mouse) P01326

          View more View less

          Entrez Gene ID: (Pig) 397415, (Bovine) 280829, (Rabbit) 100009181, (Human) 3630, (Mouse) 16333, (Mouse) 16334

          View more View less

          Function(s)
          protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity identical protein binding protein binding receptor agonist activity chaperone binding protein complex binding growth factor
          Process(es)
          negative regulation of acute inflammatory response glucose metabolic process regulation of cellular amino acid metabolic process acute-phase response G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway lipid biosynthetic process glycoprotein biosynthetic process positive regulation of nitric oxide mediated signal transduction positive regulation of glucose metabolic process positive regulation of phosphatidylinositol 3-kinase signaling lactate biosynthetic process regulation of transmembrane transporter activity positive regulation of cell migration positive regulation of protein autophosphorylation activation of protein kinase B activity negative regulation of NAD(P)H oxidase activity wound healing lipoprotein biosynthetic process negative regulation of protein catabolic process glucose homeostasis positive regulation of MAPK cascade negative regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of proteolysis negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipid catabolic process positive regulation of lipoprotein lipase activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of protein localization to nucleus positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process response to L-arginine neuron projection maintenance negative regulation of feeding behavior signal transduction feeding behavior protein secretion response to heat response to glucose positive regulation of gene expression response to nutrient levels positive regulation of insulin secretion response to food negative regulation of appetite positive regulation of mammary gland epithelial cell proliferation positive regulation of Rho protein signal transduction estradiol secretion negative regulation of apoptotic process glucose import in response to insulin stimulus positive regulation of protein secretion response to growth hormone positive regulation of peptide hormone secretion positive regulation of cell maturation negative regulation of lactation positive regulation of lactation positive regulation of blood circulation response to butyrate positive regulation of cytokine production regulation of transcription, DNA-templated cell-cell signaling negative regulation of gene expression positive regulation of neuron projection development positive regulation of cell growth regulation of protein localization nitric oxide-cGMP-mediated signaling pathway TORC1 signaling vasodilation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cell differentiation positive regulation of translation positive regulation of lipid biosynthetic process regulation of synaptic plasticity regulation of protein secretion cognition positive regulation of nitric-oxide synthase activity positive regulation of brown fat cell differentiation positive regulation of long-term synaptic potentiation cellular response to oxygen-containing compound negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process carbohydrate metabolic process glucose transport negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPK activity ER overload response activation of JUN kinase activity myoblast fusion regulation of gene expression myotube differentiation lipid catabolic process positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of phosphorylation regulation of protein binding positive regulation of phosphatidylinositol 3-kinase activity canonical Wnt signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
          It has to be done as per old AB suggested Products section.

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