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Invitrogen
UBC13 Monoclonal Antibody (4E 11)
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Product Details
37-1100
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Bacteria,
Human,
Mouse,
Plant
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4E 11
Immunogen
Recombinant human Ubc13
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. (Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bendless protein; bendless-like ubiquitin conjugating enzyme; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; epididymis secretory protein Li 71; MGC131857; MGC8489; Ubc13; UbcH13; Ubiquitin carrier protein N; ubiquitin conjugating enzyme E2N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Ubiquitin-protein ligase N; yeast UBC13 homolog
Gene Aliases: 1500026J17Rik; AL022654; BB101821; BLU; HEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN; UBCHBEN; UBC13; UBE2N
UniProt ID: (Human) P61088, (Rat) Q9EQX9, (Mouse) P61089
Entrez Gene ID: (Human) 7334, (Rat) 116725, (Mouse) 93765
nucleotide binding
RNA binding
ubiquitin-protein transferase activity
protein binding
ATP binding
transferase activity
ubiquitin protein ligase binding
ubiquitin binding
ubiquitin conjugating enzyme activity
ubiquitin-protein transferase activator activity
ligase activity
ubiquitin-like protein transferase activity
poly(A) RNA binding
ubiquitin protein ligase activity
ubiquitin-protein ligase
protein polyubiquitination
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA repair
regulation of DNA repair
postreplication repair
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
protein ubiquitination
cellular response to nutrient levels
TORC1 signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA repair
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
protein K63-linked ubiquitination
antiviral innate immune response
positive regulation of protein K63-linked ubiquitination
positive regulation of intracellular signal transduction
negative regulation of TORC1 signaling
positive regulation of double-strand break repair
histone ubiquitination
positive regulation of histone modification
regulation of histone ubiquitination
positive regulation of ubiquitin-protein transferase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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