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NeoBiotechnologies
MCM3 (Proliferation Marker) Monoclonal Antibody (MCM3/6706)
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Product Details
4172-MSM4-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
MCM3/6706
Immunogen
Recombinant fragment (aa 650-750) of human MCM3 protein.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: Jurkat or Ramos cells. Human colon or tonsil. MCF-7
Cellular Location: Nucleus.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cervical cancer proto-oncogene 5; DNA polymerase alpha holoenzyme-associated protein P1; DNA replication factor MCM3; DNA replication licensing factor MCM3; hRlf beta subunit; MCM3 minichromosome maintenance deficient 3; MGC1157; minichromosome maintenance deficient 3; P1-MCM3; p102; replication licensing factor, beta subunit; RLF subunit beta; RP1-108C2.3; unnamed protein product
Gene Aliases: HCC5; MCM3; P1-MCM3; P1.h; RLFB
UniProt ID: (Human) P25205
Entrez Gene ID: (Human) 4172
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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