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Invitrogen

HNF4A Monoclonal Antibody (H6939)

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View all (50) HNF4A antibodies

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HNF4A Monoclonal Antibody (H6939)

Product Details

417800

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

10-20 µg/mL
-

ELISA (ELISA)

3 µg/mL
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

H6939

Immunogen

Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human HNF4--alpha (1-16 aa).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

physiological saline

Contains

0.1% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532198

Product Specific Information

This antibody specifically recognizes human HNF4 alpha 7- 9 and cross reacts with mouse and rat HNF4 alpha 7- 9.

Target Information

Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is an orphan nuclear receptor. HNF4a is expressed in the liver, kidney, intestine, and pancreas. Mutation of HNF4a in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4a gene is alternatively spliced and may generate up to nine different isoforms, HNF4a1 through HNF4a9.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: alpha transcription factor 4; FLJ39654; hepatic nuclear factor 4 alpha; hepatic nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4 alpha; HNF4-alpha; HNF4A wild type; HNF4a7; HNF4a8; HNF4a9; HNF4alpha10; HNF4alpha10/11/12; HNF4alpha11; HNF4alpha12; Nuclear receptor 2A1; Nuclear receptor subfamily 2 group A member 1; TCF-14; transcription factor; Transcription factor 14; Transcription factor HNF-4

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Gene Aliases: FRTS4; HNF-4; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF-14; TCF14

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UniProt ID: (Human) P41235, (Mouse) P49698, (Rat) P22449

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Entrez Gene ID: (Human) 3172, (Mouse) 15378, (Rat) 25735

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding fatty acid binding protein binding zinc ion binding protein homodimerization activity sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding fatty-acyl-CoA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity transcription factor binding palmitoyl-CoA hydrolase activity transcription regulatory region DNA binding repressing transcription factor binding C4 zinc finger nuclear receptor
Process(es)
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter lipid metabolic process xenobiotic metabolic process sex differentiation blood coagulation negative regulation of cell proliferation response to glucose gene expression regulation of gastrulation regulation of lipid metabolic process signal transduction involved in regulation of gene expression cell differentiation negative regulation of cell growth intracellular receptor signaling pathway glucose homeostasis cholesterol homeostasis regulation of circadian rhythm negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process regulation of insulin secretion lipid homeostasis phospholipid homeostasis regulation of growth hormone receptor signaling pathway triglyceride homeostasis regulation of ornithine metabolic process transcription, DNA-templated ornithine metabolic process acyl-CoA metabolic process establishment of tissue polarity regulation of microvillus assembly negative regulation of protein import into nucleus, translocation negative regulation of tyrosine phosphorylation of Stat5 protein steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity cell-cell junction organization positive regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process negative regulation of mitotic cell cycle SMAD protein signal transduction negative regulation of activation of JAK2 kinase activity positive regulation of cholesterol homeostasis response to drug response to cAMP
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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