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Invitrogen

CYLD Monoclonal Antibody (733)

Advanced Verification
2 Published Figures
3 References
View all (19) CYLD antibodies

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CYLD Monoclonal Antibody (733)

Product Details

43-7700

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-

Immunocytochemistry (ICC/IF)

1 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Horse, Human, Mouse, Non-human primate, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

733

Immunogen

Recombinant protein derived from the N-terminus of human CYLD protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533539

Target Information

CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cyld; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; FLJ20180; FLJ31664; FLJ78684; probable ubiquitin carboxyl-terminal hydrolase CYLD; retinitis pigmentosa 1 homolog; Ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD; unnamed protein product

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Gene Aliases: 2010013M14Rik; 2900009M21Rik; BRSS; C130039D01Rik; CDMT; CYLD; CYLD1; CYLDI; EAC; FTDALS8; HSPC057; KIAA0849; LRRGT00003; MFT; MFT1; mKIAA0849; Rp1; Rp1h; SBS; TEM; USPL2

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UniProt ID: (Bovine) Q1RMU2, (Human) Q9NQC7, (Rat) Q66H62, (Mouse) Q80TQ2

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Entrez Gene ID: (Horse) 100050308, (Bovine) 536421, (Human) 1540, (Rat) 312937, (Mouse) 74256

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Function(s)
thiol-dependent ubiquitin-specific protease activity zinc ion binding protein kinase binding Lys63-specific deubiquitinase activity proline-rich region binding Lys48-specific deubiquitinase activity protein binding peptidase activity cysteine-type peptidase activity hydrolase activity metal ion binding ubiquitinyl hydrolase activity, acting on linear ubiquitin molecular_function structural constituent of ribosome thiol-dependent ubiquitinyl hydrolase activity ribosomal protein
Process(es)
ubiquitin-dependent protein catabolic process regulation of tumor necrosis factor-mediated signaling pathway Wnt signaling pathway protein deubiquitination negative regulation of NF-kappaB transcription factor activity CD4-positive or CD8-positive, alpha-beta T cell lineage commitment regulation of protein binding innate immune response regulation of B cell differentiation positive regulation of T cell differentiation negative regulation of JNK cascade homeostasis of number of cells regulation of inflammatory response positive regulation of T cell receptor signaling pathway regulation of necroptotic process regulation of microtubule cytoskeleton organization protein K63-linked deubiquitination protein K48-linked deubiquitination negative regulation of canonical Wnt signaling pathway ripoptosome assembly involved in necroptotic process negative regulation of NIK/NF-kappaB signaling regulation of cilium assembly negative regulation of p38MAPK cascade positive regulation of cellular protein localization protein linear deubiquitination immune system process proteolysis I-kappaB kinase/NF-kappaB signaling regulation of mitotic cell cycle negative regulation of type I interferon production nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of inflammatory response necroptotic process negative regulation of interleukin-18-mediated signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway cytoplasmic translation biological_process negative regulation of NF-kappaB import into nucleus negative regulation of T cell differentiation
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