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Invitrogen
Cyclophilin F Monoclonal Antibody (E11AE12BD4)
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FIGURE: 1 / 9
Cyclophilin F Antibody (45-5900) in ICC/IF
Immunofluorescent analysis of Cyclophilin F in MRC5 cells using a Cyclophilin F Monoclonal antibody (Product # 45-5900) at a concentration of 1 µg/mL. Cultured Human embryonic lung-derived fibroblasts (strain MRC5), were fixed, treated for heat-induced antigen retrieval, and permeabilized. Detection was perfomed by an AlexaFluor® 488-conjugated-goat-anti-mouse IgG1 isotype specific secondary antibody (2 µg/... View More
Product Details
45-5900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
E11AE12BD4
Immunogen
Recombinant rat Cyclophilin F
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
HEPES buffered saline
Contains
0.02% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive controls: Isolated mitochondria from Human heart, Bovine heart, Rat heart, Mouse heart, HepG2 cells; Cultured Human embryonic lung-derived fibroblasts (strain MRC5); Human cerebellum tissue; HL60 cells.
Target Information
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cyclophilin 3; Cyclophilin D; Cyclophilin F; CyP-D; CyP-M; Mitochondrial cyclophilin; mitochondrial Cyclophilin D; mitochondrial peptidyl-prolyl cis-trans isomerase; Peptidyl-prolyl cis-trans isomerase F; Peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F; PPIase F; Rotamase F; unnamed protein product
Gene Aliases: AW457192; CyP-D; CyP-F; CyP-M; CYP3; CypD; PPIase; PPIF
UniProt ID: (Human) P30405, (Bovine) P30404, (Rat) P29117, (Mouse) Q99KR7
Entrez Gene ID: (Human) 10105, (Bovine) 414346, (Rat) 282819, (Mouse) 105675
response to ischemia
protein folding
apoptotic process
response to oxidative stress
mitochondrion organization
apoptotic mitochondrial changes
regulation of proton-transporting ATPase activity, rotational mechanism
programmed cell death
negative regulation of apoptotic process
regulation of mitochondrial membrane permeability
mitochondrial depolarization
muscle structure development
necroptotic process
cellular response to hydrogen peroxide
cellular response to arsenic-containing substance
cellular response to calcium ion
negative regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation
skeletal muscle fiber differentiation
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
mitochondrial outer membrane permeabilization involved in programmed cell death
negative regulation of intrinsic apoptotic signaling pathway
protein peptidyl-prolyl isomerization
negative regulation of ATPase activity
positive regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation uncoupler activity
regulation of necrotic cell death
regulation of apoptotic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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