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Invitrogen
Pannexin 1 Polyclonal Antibody
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FIGURE: 1 / 8
Pannexin 1 Antibody (487900) in WB
Journal of neuroinflammation 2024 -
Different alterations of connexin and pannexin expression in the cochlea and auditory cortex after the oto/neurotoxic insult. A , B Representative bands of western blot showing high levels of Cx43 and Panx1 in the auditory cortex (ACx) of styrene-treated animals compared to controls. Bar graphs show optical density values in all samples (Cx43 n = 3 animals/group; Student's t test, p = 0.03; Panx1 n = 3 anim... View More
Product Details
487900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the N-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), which is identical to rat and human sequences.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Pannexin-1
Gene Aliases: AI847747; Panx1
UniProt ID: (Mouse) Q9JIP4
Entrez Gene ID: (Mouse) 55991
protease binding
actin binding
receptor binding
gap junction channel activity
calcium channel activity
protein binding
channel activity
wide pore channel activity
leak channel activity
ion channel binding
protein heterodimerization activity
actin filament binding
gap junction hemi-channel activity
scaffold protein binding
response to ischemia
transport
ion transport
cation transport
calcium ion transport
cell-cell signaling
response to ATP
protein hexamerization
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
transmembrane transport
calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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