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Proteintech
BMI1 Monoclonal Antibody (2E10A11)
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Product Details
66161-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2E10A11
Immunogen
BMI1 Fusion Protein Ag21284 (1-326 aa encoded by BC011652)
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Amount
85.5 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody reacts with the 37 kDa BMI1 protein.
Immunogen sequence: MHRTTRIKI TELNPHLMCV LCGGYFIDAT TIIECLHSFC KTCIVRYLET SKYCPICDVQ VHKTRPLLNI RSDKTLQDIV YKLVPGLFKN EMKRRRDFYA AHPSADAANG SNEDRGEVAD EDKRIITDDE IISLSIEFFD QNRLDRKVNK DKEKSKEEVN DKRYLRCPAA MTVMHLRKFL RSKMDIPNTF QIDVMYEEEP LKDYYTLMDI AYIYTWRRNG PLPLKYRVRP TCKRMKISHQ RDGLTNAGEL ESDSGSDKAN SPAGGIPSTS SCLPSPSTPV QSPHPQFPHI SSTMNGTSNS PSGNHQSSFA NRPRKSSVNG SSATSSG (1-326 aa encoded by BC011652)
Target Information
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B lymphoma Mo-MLV insertion region 1; B lymphoma Mo-MLV insertion region 1 homolog; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; COMMD3; murine leukemia viral (bmi-1) oncogene homolog; Pcgf4 antibody; Polycomb complex protein BMI-1; polycomb group protein Bmi1; polycomb group ring finger 4; Polycomb group RING finger protein 4; putative; RING finger protein 51; RP11-573G6.1
Gene Aliases: AW546694; Bmi-1; BMI1; flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
UniProt ID: (Human) P35226, (Mouse) P25916
Entrez Gene ID: (Human) 648, (Mouse) 12151
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
in utero embryonic development
DNA methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
humoral immune response
brain development
cellular process
chromatin modification
histone acetylation
histone ubiquitination
rostrocaudal neural tube patterning
positive regulation of B cell proliferation
positive regulation of immature T cell proliferation in thymus
somatic stem cell division
embryonic skeletal system morphogenesis
embryonic skeletal system development
regulation of catalytic activity
hematopoietic stem cell homeostasis
negative regulation of apoptotic signaling pathway
chromatin organization
chromatin remodeling
methylation-dependent chromatin silencing
segment specification
regulation of gene expression
hemopoiesis
negative regulation of gene expression, epigenetic
positive regulation of fibroblast proliferation
positive regulation of ubiquitin-protein transferase activity
cellular response to interleukin-1
cellular response to dexamethasone stimulus
regulation of kidney development
apoptotic signaling pathway
regulation of adaxial/abaxial pattern formation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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