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STAT5A Monoclonal Antibody (1F10F6)

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View all (57) STAT5 alpha antibodies

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STAT5A Monoclonal Antibody (1F10F6)

Product Details

66459-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:16,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:400
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1F10F6

Immunogen

STAT5A Fusion Protein Ag19546 (445-794 aa encoded by BC027036)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

150 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ESQFSVGSN ELVFQVKTLS LPVVVIVHGS QDHNATATVL WDNAFAEPGR VPFAVPDKVL WPQLCEALNM KFKAEVQSNR GLTKENLVFL AQKLFNNSSS HLEDYSGLSV SWSQFNRENL PGWNYTFWQW FDGVMEVLKK HHKPHWNDGA ILGFVNKQQA HDLLINKPDG TFLLRFSDSE IGGITIAWKF DSPERNLWNL KPFTTRDFSI RSLADRLGDL SYLIYVFPDR PKDEVFSKYY TPVLAKAVDG YVKPQIKQVV PEFVNASADA GGSSATYMDQ APSPAVCPQA PYNMYPQNPD HVLDQDGEFD LDETMDVARH VEELLRRPMD SLDSRLSPPA GLFTSARGSL S (445-794 aa encoded by BC027036)

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor; transcription factor; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; STAT; STAT5B; unnamed protein product

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Gene Aliases: AA959963; MGF; Mpf; STAT5; STAT5A

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UniProt ID: (Pig) Q9TUZ1, (Human) P42229, (Rat) Q62771, (Mouse) P42230

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Entrez Gene ID: (Pig) 397550, (Human) 6776, (Rat) 24918, (Mouse) 20850

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding phosphate ion binding sequence-specific DNA binding DNA-binding transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding double-stranded DNA binding signal transducer activity protein phosphatase binding DNA-binding transcription factor
Process(es)
luteinization natural killer cell differentiation JAK-STAT cascade female pregnancy lactation positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway lipid storage regulation of cell adhesion regulation of epithelial cell differentiation mammary gland development positive regulation of interleukin-2 production positive regulation of multicellular organism growth positive regulation of activated T cell proliferation T cell homeostasis negative regulation of apoptotic process positive regulation of B cell differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter development of secondary female sexual characteristics positive regulation of inflammatory response JAK-STAT cascade involved in growth hormone signaling pathway mitotic cell cycle positive regulation of endothelial cell proliferation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter defense response signal transduction cell proliferation taurine metabolic process lymphocyte differentiation B cell differentiation erythrocyte differentiation eosinophil differentiation positive regulation of natural killer cell differentiation mast cell apoptotic process negative regulation of mast cell apoptotic process myeloid cell apoptotic process negative regulation of myeloid cell apoptotic process T cell differentiation in thymus interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway reelin-mediated signaling pathway interleukin-5-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway interleukin-3-mediated signaling pathway thrombopoietin-mediated signaling pathway regulation of multicellular organism growth T cell proliferation positive regulation of T cell proliferation regulation of cell proliferation natural killer cell mediated cytotoxicity gamma-delta T cell differentiation response to peptide hormone positive regulation of blood vessel endothelial cell migration positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation positive regulation of natural killer cell mediated cytotoxicity development of secondary male sexual characteristics Peyer's patch development activated T cell proliferation mast cell differentiation positive regulation of mast cell differentiation prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development mast cell proliferation positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus regulation of hemopoiesis negative regulation of T-helper 17 cell lineage commitment allantoin metabolic process citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process peptidyl-tyrosine phosphorylation response to nutrient levels prolactin signaling pathway positive regulation of interleukin-2 biosynthetic process response to ethanol creatinine metabolic process multicellular organismal reproductive process mammary gland involution
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