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Invitrogen
TAX1BP1 Recombinant Rabbit Monoclonal Antibody (4H2L18)
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FIGURE: 1 / 4
TAX1BP1 Antibody (702840) in ICC/IF
For immunofluorescence analysis, HeLa cells were fixed and permeabilized for detection of endogenous TAX1BP1 using Anti- TAX1BP1 Recombinant Rabbit Monoclonal Antibody (Product # 702840, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000 dilution). Panel a) shows representative cells that were stained for detection and localization of TAX1BP1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant wit... View More
Product Details
702840
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
4H2L18
Immunogen
Protein corresponding to human TAX1BP1 [aa406-aa541]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Dog, Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1-binding protein 1; Tax1-binding protein 1 homolog; TAX1BP1; TRAF6-binding protein; TRAF6-binding protein homolog; unnamed protein product
Gene Aliases: 1200003J11Rik; 1700069J21Rik; AA930106; CALCOCO3; D6Ertd404e; D6Ertd772e; PRO0105; T6BP; TAX1BP1; TXBP151
UniProt ID: (Human) Q86VP1, (Mouse) Q3UKC1
Entrez Gene ID: (Human) 8887, (Mouse) 52440
apoptotic process
negative regulation of NF-kappaB transcription factor activity
negative regulation of apoptotic process
immune system process
cytoplasmic pattern recognition receptor signaling pathway
autophagy
negative regulation of tumor necrosis factor-mediated signaling pathway
toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
protein K48-linked ubiquitination
protein localization to phagocytic vesicle
negative regulation of interleukin-1-mediated signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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