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FIGURE: 1 / 2
Granulins Antibody (710191) in ICC/IF
Immunofluorescent analysis of Granulins in HEK293 cells using a Granulins Recombinant Rabbit Superclonal™ Antibody (Product # 710191) followed by detection using an Alexa Fluor 488-conjugated Goat anti-Rabbit secondary antibody (green) (Image A). Nuclei were stained using DAPI (Image B) and a composite image showing actin stained using Alexa Fluor 594 phalloidin (red). Image D is a composite image showing m... View More
Product Details
710191
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
2HCLC
Immunogen
Peptide corresponding to amino acids 573-588 of human PC cell-derived growth factor
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with equine, mouse, rabbit and rat based on sequence homology.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
PCDGF is a glycoprotein and growth factor involved in the regulation of mitosis, early embryonic development, cell division, cell migration, cell survival, and hypothalamic differentiation. PCDGF is also known as progranulin because it is the precursor for smaller proteins known as epithelins or granulins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acrogranin; epithelin; Epithelin precursor; glycoprotein 88; Glycoprotein of 88 Kda; GP88; Granulin precursor; granulin-epithelin; granulins; PC cell-derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin; unnamed protein product
Gene Aliases: CLN11; FTD2; GEP; GP88; GRN; PCDGF; PEPI; PGRN
UniProt ID: (Human) P28799
Entrez Gene ID: (Human) 2896
trophectodermal cell proliferation
blastocyst hatching
astrocyte activation involved in immune response
microglial cell activation involved in immune response
lysosome organization
lysosomal transport
lysosomal lumen acidification
signal transduction
embryo implantation
positive regulation of cell proliferation
positive regulation of endothelial cell migration
positive regulation of cell migration
locomotory exploration behavior
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of angiogenesis
negative regulation of innate immune response
positive regulation of axon regeneration
epithelial cell proliferation
positive regulation of epithelial cell proliferation
regulation of inflammatory response
negative regulation of inflammatory response
regulation of developmental process
protein stabilization
positive regulation of cellular component organization
establishment of localization in cell
retina development in camera-type eye
negative regulation of respiratory burst involved in inflammatory response
maintenance of synapse structure
positive regulation of inflammatory response to wounding
positive regulation of defense response to bacterium
negative regulation of neutrophil activation
positive regulation of protein folding
negative regulation of microglial cell activation
positive regulation of trophectodermal cell proliferation
lysosomal protein catabolic process
positive regulation of aspartic-type peptidase activity
regulation of lysosome organization
positive regulation of lysosome organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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