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Invitrogen

CXCL10 Recombinant Superclonal™ Antibody (10HCLC)

View all (40) CXCL10 (IP-10) antibodies

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Product Details

710399

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

10HCLC

Immunogen

proprietary

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532707

Product Specific Information

This antibody is predicted to react with rat and porcine based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

IP-10 (interferon-gamma induced protein 10 kD; in mouse, also called cytokine responsive gene 2, Crg-2, or mob-1) is a highly inducible, primary response gene that belongs to the CXC chemokine superfamily. It was first cloned in 1985. The biological functions of IP-10 are still unclear. Like Mig, IP-10 has no activity on neutrophils. Its functions include stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Mig and IP-10 share the same receptor, CXCR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 10 kDa interferon gamma-induced protein; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 10; C7; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; gamma IP10; Gamma-IP10; H-IP-10; interferon activated gene 10; Interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; interferon-inducible cytokine IP-10; M-IP-10; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10

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Gene Aliases: C7; CRG-2; Crg2; CXCL10; gIP-10; IFI10; INP10; IP-10; IP10; mob-1; SCYB10

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UniProt ID: (Human) P02778, (Mouse) P17515

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Entrez Gene ID: (Human) 3627, (Mouse) 15945

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Function(s)
receptor binding cytokine activity protein binding chemokine activity heparin binding cAMP-dependent protein kinase regulator activity chemoattractant activity CXCR chemokine receptor binding CXCR3 chemokine receptor binding chemokine
Process(es)
positive regulation of leukocyte chemotaxis chemotaxis defense response inflammatory response immune response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway cell-cell signaling muscle organ development blood circulation positive regulation of cell proliferation response to bacterium response to gamma radiation T cell chemotaxis regulation of T cell chemotaxis response to auditory stimulus negative regulation of angiogenesis positive regulation of cell migration neutrophil chemotaxis killing of cells of other organism response to lipopolysaccharide response to vitamin D cellular response to heat endothelial cell activation regulation of cell proliferation regulation of apoptotic process negative regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter positive chemotaxis positive regulation of release of sequestered calcium ion into cytosol defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis cellular response to interleukin-17 cellular response to virus antiviral innate immune response regulation of endothelial tube morphogenesis negative regulation of myoblast fusion positive regulation of T cell migration positive regulation of cAMP metabolic process positive regulation of cAMP-mediated signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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