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Invitrogen
Annexin A1 Polyclonal Antibody
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FIGURE: 1 / 48
Annexin A1 Antibody (71-3400) in ICC/IF
Immunofluorescent analysis of Annexin-1 Antibody was done on 70% confluent log phase U87-MG cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with Annexin-1 Antibody (Product # 71-3400) at 1:1000 dilution in 1% BSA and incubated for 3 hours at room temperat... View More
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.jpg?time=20240507?time=20240507 "Annexin A1 Antibody (71-3400) in WB")
.jpg?time=20240507?time=20240507 "Annexin A1 Antibody (71-3400) in WB")
Product Details
71-3400
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full-length human recombinant Annexin I protein purified from yeast.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is specific for the Annexin I protein and does not cross-react with other Annexins.Reactivity with Annexin I was confirmed by western blotting using total lysates derived from human fibroblasts. Positive control lysates used: human fibroblasts, mouse kidney, mouse lung, adult rat and mouse brain.
Target Information
Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ANAX1; Annexin 1 (p35) (Lipocortin 1); Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANXA1; Calpactin II; Calpactin-2; Chromobindin-9; epididymis secretory sperm binding protein; lipocortin 1; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1; unnamed protein product
Gene Aliases: Anx-1; Anx-A1; ANX1; ANXA1; C430014K04Rik; Lpc-1; LPC1; p35
UniProt ID: (Human) P04083, (Mouse) P10107, (Rat) P07150
Entrez Gene ID: (Human) 301, (Mouse) 16952, (Rat) 25380
phosphatidylserine binding
phospholipase inhibitor activity
receptor binding
calcium ion binding
protein binding
phospholipid binding
calcium-dependent phospholipid binding
lipid binding
phospholipase A2 inhibitor activity
metal ion binding
calcium-dependent protein binding
cadherin binding involved in cell-cell adhesion
single-stranded DNA binding
single-stranded RNA binding
helicase activity
structural molecule activity
protein binding, bridging
double-stranded DNA-dependent ATPase activity
annealing helicase activity
protein homodimerization activity
calcium-binding protein
neutrophil homeostasis
adaptive immune response
immune system process
monocyte chemotaxis
regulation of leukocyte migration
phagocytosis
inflammatory response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of cell shape
myoblast migration involved in skeletal muscle regeneration
peptide cross-linking
actin cytoskeleton organization
keratinocyte differentiation
positive regulation of vesicle fusion
regulation of interleukin-1 production
negative regulation of interleukin-8 production
positive regulation of interleukin-2 production
positive regulation of neutrophil apoptotic process
cellular response to vascular endothelial growth factor stimulus
positive regulation of T cell proliferation
neutrophil activation
regulation of cell proliferation
negative regulation of apoptotic process
innate immune response
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
negative regulation of exocytosis
alpha-beta T cell differentiation
regulation of hormone secretion
arachidonic acid secretion
regulation of inflammatory response
negative regulation of transport
positive regulation of multicellular organismal process
cellular response to glucocorticoid stimulus
granulocyte chemotaxis
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of wound healing
neutrophil clearance
cell-cell adhesion
positive regulation of G1/S transition of mitotic cell cycle
DNA strand renaturation
insulin secretion
positive regulation of prostaglandin biosynthetic process
DNA duplex unwinding
DNA rewinding
positive regulation of apoptotic process
negative regulation of protein secretion
cellular response to hydrogen peroxide
prolactin secretion
negative regulation of phospholipase A2 activity
negative regulation of interleukin-8 secretion
response to hormone
response to X-ray
response to organic cyclic compound
prostate gland development
endocrine pancreas development
response to corticosteroid
response to estradiol
gliogenesis
response to drug
response to peptide hormone
estrous cycle
response to glucocorticoid
hepatocyte differentiation
response to interleukin-1
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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