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Invitrogen
SALL4 Polyclonal Antibody
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FIGURE: 1 / 5
SALL4 Antibody (720030) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized A-431cells for detection of Sall4 using Anti-Sall4 Rabbit Polyclonal Antibody (Product # 720030, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 0.4 µg/mL, 1:2500). Panel a) shows representative cells that were stained for detection and localization of Sall4 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938, 1:50). Panel... View More
Product Details
720030
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Multiple peptides against Human Sall4 (aa 7-21, 1038-1053, 808-822)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Rat, Mouse, Pig, Bovine, Rabbit and Dog.
720030 can be used for immunofluorescence analysis of Sall4 in human iPSCs and human ESC lines.
Target Information
Sall4 protein is encoded by the Sall4 gene located on chromosome 20 in humans and belongs to the Spalt-like protein family. It plays an important role in somatic stem cell maintenance and is studied as a stem cell biomarker. It is a zinc finger transcription factor that is upregulated during development and shown to interact with Oct4 and Sox2. It also forms a complex with Nanog to maintain the pluripotency of Embryonic Stem cells (ESCs). Several current research studies focus on its function as an oncogene and tumor biomarker. Some of the reported target genes of Sall4 include p53, Bmi-1, Bcl2 and XIAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ1112F19.1; Sal-like protein 4; Zinc finger protein 797; Zinc finger protein SALL4
Gene Aliases: 5730441M18Rik; AA407717; AL022809; AW536104; C330011P20Rik; C78083; C78563; DRRS; HSAL4; IVIC; SALL4; Tex20; ZNF797
UniProt ID: (Human) Q9UJQ4, (Mouse) Q8BX22
Entrez Gene ID: (Human) 57167, (Mouse) 99377
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
inner cell mass cell proliferation
neural tube closure
ventricular septum development
regulation of transcription from RNA polymerase II promoter
heart development
tissue development
neural tube development
embryonic limb morphogenesis
somatic stem cell population maintenance
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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