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Invitrogen

MSX1 Polyclonal Antibody

View all (17) MSX1 antibodies

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MSX1 Polyclonal Antibody

Product Details

720172

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Protein corresponding to Human MSX1 (aa 1-303)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 30% glycerol, 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609062

Product Specific Information

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.

This antibody is predicted to react with Monkey, Horse and Rabbit.

Target Information

MSX1 is a member of the muscle segment homeobox gene family. It functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. MSX1 may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in the gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; msh homeo box 1; Msh homeobox 1-like protein; msh homeobox homolog 1; unnamed protein product

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Gene Aliases: ECTD3; HOX7; HYD1; MSX1; STHAG1

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UniProt ID: (Human) P28360

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Entrez Gene ID: (Human) 4487

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding protein binding sequence-specific DNA binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis in utero embryonic development epithelial to mesenchymal transition heart morphogenesis cardiac conduction system development epithelial to mesenchymal transition involved in endocardial cushion formation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development muscle organ development negative regulation of cell proliferation organ morphogenesis anterior/posterior pattern specification mesenchymal cell proliferation negative regulation of gene expression pituitary gland development signal transduction involved in regulation of gene expression negative regulation of cell growth embryonic limb morphogenesis BMP signaling pathway positive regulation of BMP signaling pathway forebrain development midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth odontogenesis regulation of odontogenesis positive regulation of odontogenesis embryonic digit morphogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator nose development positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic morphogenesis inner ear development stem cell differentiation protein stabilization negative regulation of striated muscle cell differentiation cartilage development palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development cell surface receptor signaling pathway involved in heart development cellular response to nicotine activation of meiosis mesenchymal cell apoptotic process negative regulation of odontoblast differentiation positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of mesenchymal cell apoptotic process
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