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Invitrogen
HTR2C Polyclonal Antibody
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FIGURE: 1 / 2
HTR2C Antibody (720264) in ICC/IF
For immunofluorescence analysis, SHSY-5Y cells were fixed and permeabilized for detection of endogenous HTR2C using Anti-HTR2C Rabbit Polyclonal Antibody (Product # 720264, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of HTR2C protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel ... View More
Product Details
720264
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Protein corresponding to Human HTR2C (aa 236-311)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Horse, Pig, Goat, Cat and Rabbit
Target Information
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT1c receptor; 5-HT2C receptor; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; 5HT2C Receptor; HGNC:5295; RP11-810O3.1; RP23-15B7.1; serotonin; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; serotonin receptor; Serotonin receptor 2C; unnamed protein product
Gene Aliases: 5-HT1C; 5-HT2C; 5-HT2cR; 5-HTR2C; 5HT1c; 5HTR2C; HTR1C; HTR2C; SR1
UniProt ID: (Human) P28335, (Mouse) P34968
Entrez Gene ID: (Human) 3358, (Mouse) 15560
Gq/11-coupled serotonin receptor activity
G-protein coupled receptor activity
G-protein coupled serotonin receptor activity
protein binding
neurotransmitter receptor activity
identical protein binding
serotonin binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
serotonin receptor activity
signal transducer activity
drug binding
G-protein coupled receptor
behavioral fear response
cellular calcium ion homeostasis
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
locomotory behavior
feeding behavior
positive regulation of phosphatidylinositol biosynthetic process
cGMP-mediated signaling
regulation of neurological system process
regulation of appetite
regulation of corticotropin-releasing hormone secretion
positive regulation of fat cell differentiation
positive regulation of calcium-mediated signaling
release of sequestered calcium ion into cytosol
positive regulation of ERK1 and ERK2 cascade
G protein-coupled serotonin receptor signaling pathway
cGMP biosynthetic process
behavior
positive regulation of gamma-aminobutyric acid secretion
positive regulation of acetylcholine secretion, neurotransmission
phospholipase D-activating G-protein coupled receptor signaling pathway
behavioral response to nicotine
negative regulation of locomotion
response to drug
positive regulation of vasoconstriction
negative regulation of dopamine metabolic process
inositol phosphate-mediated signaling
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of sensory perception of pain
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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