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Invitrogen
CRHR1 Polyclonal Antibody
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FIGURE: 1 / 3
CRHR1 Antibody (720290) in ICC/IF
Immunofluorescence was performed on HEK-293 cells transfected with CRHR1 expression plasmid. 24 hours post transection, cells were fixed and permeabilized for detection of CRHR1 using Anti-CRHR1 Rabbit Polyclonal Antibody (Product # 720290, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CRHR1 protein (green), Panel b) is stained for nuclei (blue) using ... View More
Product Details
720290
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human CRHR1 (aa 425-445)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Pig, Rat and Mouse.
Target Information
Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Corticotropin-releasing factor receptor 1; corticotropin-releasing factor receptor variant 1j; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; CRF 1 receptor; Crf receptor 1; Crf type 1; CRF-R-1; CRF-R1; CRF-R1alpha; Crf1 receptor; CRF1I; CRFR-1; CRH receptor subtype-1 isoform-3; CRH-R-1; CRH-R1; CRH-R1d; type 1 CRH receptor; CRH-R1h; CRHR1e; CRHR1f; CRHR1g; G protein-coupled receptor; seven transmembrane helix receptor
Gene Aliases: CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1; CRHR1L
UniProt ID: (Human) P34998, (Mouse) P35347
Entrez Gene ID: (Human) 1394, (Mouse) 12921
transmembrane signaling receptor activity
G-protein coupled receptor activity
protein binding
G-protein coupled peptide receptor activity
corticotrophin-releasing factor receptor activity
corticotropin-releasing hormone receptor activity
corticotropin-releasing hormone binding
G-protein alpha-subunit binding
signal transducer activity
protein complex binding
peptide binding
transmembrane signal receptor
immune response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
female pregnancy
parturition
hormone-mediated signaling pathway
adrenal gland development
cellular response to hormone stimulus
exploration behavior
fear response
behavioral response to ethanol
regulation of transport
corticotropin secretion
general adaptation syndrome, behavioral process
cellular response to corticotropin-releasing hormone stimulus
negative regulation of voltage-gated calcium channel activity
regulation of corticosterone secretion
response to hypoxia
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
memory
feeding behavior
visual learning
regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
negative regulation of epinephrine secretion
locomotory exploration behavior
positive regulation of mast cell degranulation
behavioral response to cocaine
regulation of synaptic plasticity
behavioral response to pain
response to electrical stimulus
long-term synaptic potentiation
negative regulation of neuron death
negative regulation of feeding behavior
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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