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Invitrogen
CRHR2 Polyclonal Antibody
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FIGURE: 1 / 3
CRHR2 Antibody (720291) in ICC/IF
Immunofluorescence was performed on HEK-293 cells transfected with CRHR2 expression plasmid. 24 hours post transection, cells were fixed and permeabilized for detection of CRHR2 using Anti-Corticotropin releasing hormone receptor 2 Rabbit Polyclonal Antibody (Product # 720291, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CRHR2 protein (green), Panel b... View More
Product Details
720291
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human CRHR2 (aa 24-38)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Pig, Rat and Mouse.
Target Information
Corticotropin-releasing hormone (CRH; 122560) is a 41-amino acid peptide synthesized in the hypothalamus, and play a role in the neuroregulation, responses to stress and immune challenge. Corticotropin Releasing Factor Receptor 2 (CRHR2) was the receptor of CRH. The sepression of CRHR2 has been reported in various regions of the brain as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: corticotropin releasing factor receptor type 2 beta; corticotropin-releasing factor 2; Corticotropin-releasing factor receptor 2; Corticotropin-releasing hormone receptor 2; CRF 2 receptor; CRF-R-2; CRF-RB; CRF2a-desQ; CRF2d; CRF2e; CRF2f; CRF2g; CRFR-2; CRH-R-2; CRH-R2; Crh2 receptor; G protein-coupled receptor; G-protein linked receptor; Heart and muscle corticotropin-releasing factor receptor; HM-CRF; unnamed protein product
Gene Aliases: CRF-R2; CRF-RB; CRF2; CRF2R; CRFR2; CRFR2alpha; CRFR2beta; CRH2R; CRHR2; HM-CRF
UniProt ID: (Human) Q13324, (Mouse) Q60748
Entrez Gene ID: (Human) 1395, (Mouse) 12922
transmembrane signaling receptor activity
G-protein coupled receptor activity
protein binding
G-protein coupled peptide receptor activity
corticotrophin-releasing factor receptor activity
peptide hormone binding
corticotropin-releasing hormone receptor activity
signal transducer activity
hormone activity
transmembrane signal receptor
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
long-term synaptic potentiation
cellular response to corticotropin-releasing hormone stimulus
actin filament organization
protein kinase C-activating G-protein coupled receptor signaling pathway
positive regulation of heart rate
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of serotonin secretion
negative regulation of angiogenesis
sensory perception of pain
positive regulation of cAMP metabolic process
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
positive regulation of interleukin-6 production
negative regulation of epinephrine secretion
positive regulation of stress-activated MAPK cascade
negative regulation of luteinizing hormone secretion
gastric motility
catecholamine biosynthetic process
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
positive regulation of blood pressure
negative regulation of follicle-stimulating hormone secretion
skeletal muscle tissue growth
positive regulation of NF-kappaB transcription factor activity
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
negative regulation of calcium ion import
negative regulation of feeding behavior
negative regulation of defecation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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