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Invitrogen

p38 MAPK alpha Monoclonal Antibody (PS1009)

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Product Details

82382

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Non-human primate, Pig, Rat, Yeast

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

PS1009

Immunogen

Recombinant mitogen-activated protein kinase 14

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

62 µg/mL

Amount

6.2 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1185593

Product Specific Information

82382 targets MAPK14 in Western blot, immunofluorescence, immunocytochemistry, and flow cytometry applications and shows reactivity with human, mouse, monkey, pig, S. cerevisiae, and rat samples. 82382 does not cross-react with either JNK/SAPK or p42/44 MAP Kinase. MAPK14 has a predicted molecular weight of approximately 43 kDa.

Store at -20°C and do not aliquot.

Target Information

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CRK1; CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug binding protein 1; Cytokine suppressive anti-inflammatory drug-binding protein; cytokine-supressive anti-inflammatory drug binding protein; EC 2.7.11.24; encoded by transcript variant 4; p38 MAP kinase; encoded by transcript variant 5; p38 MAP kinase; ERK1; ERT2; MAP 14; MAP kinase 1; MAP kinase 14; MAP kinase 2; MAP kinase MXI2; MAP kinase p38; MAP kinase p38 alpha; MAP kinase p38alpha; MAPK 14; MAPK1 antibody; MAPK14; MAX-interacting protein 2; mitogen activated protein kinase 14; Mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; Mitogen-activated protein kinase p38 alpha; MK14; OTTHUMP00000216563; OTTHUMP00000216566; p38 alpha; p38 alpha/Mxi2; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38alpha Exip; reactive kinase; RP1-179N16.5; SAPK2a; SAPK2a; CSAIDS binding protein 1; Stress-activated protein kinase 2a; tRNA synthetase cofactor p38; unnamed protein product

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Gene Aliases: CRK1; CSBP; CSBP1; CSBP2; CSPB1; EXIP; Hog; MAPK14; MXI2; p38; p38-alpha; p38a; p38ALPHA; p38Hog; p38MAPK; PRKM14; PRKM15; RK; SAPK2A

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UniProt ID: (Human) Q16539, (Dog) O02812, (Mouse) P47811

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Entrez Gene ID: (Pig) 100156630, (Human) 1432, (Dog) 403856, (Rat) 81649, (Mouse) 26416

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity protein binding ATP binding kinase activity transferase activity enzyme binding protein phosphatase binding mitogen-activated protein kinase p38 binding NFAT protein binding protein serine kinase activity protein C-terminus binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
DNA damage checkpoint MAPK cascade cell morphogenesis cartilage condensation angiogenesis osteoblast differentiation placenta development response to dietary excess chondrocyte differentiation negative regulation of inflammatory response to antigenic stimulus glucose metabolic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process chemotaxis cellular response to DNA damage stimulus signal transduction cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway skeletal muscle tissue development positive regulation of gene expression positive regulation of myotube differentiation fatty acid oxidation platelet activation regulation of ossification osteoclast differentiation stress-activated protein kinase signaling cascade positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide response to lipopolysaccharide positive regulation of interleukin-12 production response to insulin tumor necrosis factor-mediated signaling pathway negative regulation of hippo signaling intracellular signal transduction cellular response to vascular endothelial growth factor stimulus response to muscle stretch p38MAPK cascade positive regulation of protein import into nucleus signal transduction in response to DNA damage positive regulation of blood vessel endothelial cell migration positive regulation of erythrocyte differentiation positive regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter glucose import positive regulation of glucose import vascular endothelial growth factor receptor signaling pathway stem cell differentiation striated muscle cell differentiation positive regulation of muscle cell differentiation stress-activated MAPK cascade protein maturation positive regulation of cardiac muscle cell proliferation bone development pyroptosis 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to tumor necrosis factor cellular response to ionizing radiation cellular response to UV-B negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation cellular senescence stress-induced premature senescence cellular response to virus regulation of synaptic membrane adhesion regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion NLRP1 inflammasome complex assembly positive regulation of reactive oxygen species metabolic process smooth muscle contraction phosphorylation positive regulation of phosphorylation cell motility positive regulation of sequence-specific DNA binding transcription factor activity transcription, DNA-templated protein phosphorylation response to glucose myoblast differentiation involved in skeletal muscle regeneration peptidyl-serine phosphorylation protein autophosphorylation
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