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Bethyl Laboratories
Rad6 Polyclonal Antibody
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Product Details
A300-281A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
N-terminus of Human ubiquitin-conjugating enzyme E2A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat, D. melanogaster, Bovine and Rabbit
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2 ubiquitin-conjugating enzyme A; HHR6A (Human homologue of yeast RAD 6); putative; HR6A; RAD6 homolog A; Ubiquitin carrier protein A; Ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); ubiquitin-conjugating enzyme E2A, RAD6 homolog; ubiquitin-conjugating enzyme HR6A; Ubiquitin-protein ligase A; unnamed protein product
Gene Aliases: HHR6A; HR6A; Mhr6a; MRXS30; MRXSN; RAD6A; UBC2; UBE2A
UniProt ID: (Human) P49459, (Mouse) Q9Z255
Entrez Gene ID: (Human) 7319, (Mouse) 22209
G2/M transition of mitotic cell cycle
protein polyubiquitination
cytoplasmic translation
DNA repair
postreplication repair
chromatin organization
chromatin remodeling
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
response to UV
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K48-linked ubiquitination
protein K11-linked ubiquitination
positive regulation of mitophagy
in utero embryonic development
positive regulation of cell proliferation
histone ubiquitination
histone H2A ubiquitination
protein autoubiquitination
maternal process involved in female pregnancy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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